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The laboratory is focused on elucidating the mechanisms driving diffuse high-grade glioma (HGG) in children. In children and adults, diffuse high-grade gliomas (HGGs), including Grade III anaplastic astrocytomas and Grade IV glioblastomas, share a devastating outcome, with median survival slightly greater than one year, and five-year survival of 10-25%. Although HGGs from different age groups share related gene expression signatures, histopathological features, and frequent mutations in common pathways, there are a number of distinguishing features of pediatric HGG that indicate a unique pathogenesis. While adult glioblastomas arise predominantly in the cerebral cortex, in children, a broader spectrum of anatomical locations are more frequently involved, including the occurrence of diffuse intrinsic pontine gliomas (DIPGs), which arise in the brainstem.
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CANCER AND METASTASIS REVIEWSno. 2 (2023): 367-388
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Barbara S. Paugh, Xiaoyan Zhu,Chunxu Qu,Raelene Endersby,Alexander K. Diaz, Junyuan Zhang,Dorine A. Bax,Diana Carvalho,Rui M. Reis,Arzu Onar-Thomas,Alberto Broniscer,Cynthia Wetmore,
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Cancer Researchno. 7_Supplement (2023): 3562-3562
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NEURO-ONCOLOGY (2023)
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