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职业迁徙
个人简介
Our laboratory focuses on understanding how the RIG-I like receptors detect, respond, and regulate immunity to viral infection. The RIG‑I-like receptors, which include RIG-I, MDA5, and LGP2, are expressed basally in nearly all cell types in the body and are induced to increased levels during viral infection and in response to type I IFNs. Using West Nile virus, an emerging RNA virus that is the leading cause of mosquito-borne encephalitis in humans within the United States, we have been dissecting the host immune response to infection. Through these studies, we have identified that the RIG-I like receptors are essential for protection, triggering type I IFN-mediated responses and regulating innate immune, humoral and cell-mediated responses. Current areas of research include defining virus-host interactions that regulate immunity to Flavivirus infection, understanding how the RIG-I like receptors regulate B and T cell immunity, and how the RIG-I like receptors can be targeted to serve as potential vaccine adjuvants.
研究兴趣
论文共 247 篇作者统计合作学者相似作者
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Pediatricsno. 3 (2024)
Science translational medicineno. 747 (2024): eadl1722-eadl1722
Kathryn M. Moore, Adam-Nicolas Pelletier,Stacey Lapp, Amanda Metz, Gregory K. Tharp,Michelle Lee,Swati Sharma Bhasin, Manoj Bhasin,Rafick-Pierre Sékaly,Steven E. Bosinger,Mehul S. Suthar
biorxiv(2024)
Jacco Boon,Nadia Soudani,Traci Bricker,Tamarand Darling, Kuljeet Seehra,Nita Patel,Mimi Guebre-Xabier,Gale Smith,Mehul Suthar,Ali Ellebedy,Meredith Davis-Gardner
Research square (2024)
Meenakshi Kar, Katherine E.E. Johnson,Abigail Vanderheiden,Elizabeth J. Elrod, Katharine Floyd,Elizabeth Geerling,E. Taylor Stone, Eduardo Salinas,Stephanie Banakis, Wei Wang, Shruti Sathish, Swathi Shrihari,
biorxiv(2024)
Audrey Lee,Katharine Floyd, Shengyang Wu,Zhuoqing Fang,Tze Kai Tan, Heather M. Froggatt,John M. Powers,Sarah R. Leist,Kendra L. Gully, Miranda L. Hubbard,Chunfeng Li, Harold Hui,
Sheikh Abdul Rahman,Ramireddy Bommireddy, Nanda Kishore Routhu,Lilin Lai, Christopher D. Pack, Sampath Ramachandiran,Mehul S. Suthar, Shaker J. C. Reddy,Periasamy Selvaraj,Rama Rao Amara
crossref(2024)
SCIENCE IMMUNOLOGYno. 94 (2024): eadi8039-eadi8039
Shilpi Jain,Sanjeev Kumar, Lilin Lai,Susanne Linderman, Ansa A. Malik,Madison L. Ellis,Sucheta Godbole, Daniel Solis,Malaya K. Sahoo, Kareem Bechnak, Isabel Paredes, Ralph Tanios,
biorxiv(2024)
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