In 1999, she joined an Imperial spin off (Microscience Ltd. now Emergent BioSolutions, Inc.) to work as a Senior Scientist on the molecular characterization of a vaccine strain. In 2001, she moved to the European Molecular Biology Laboratory's European Bioinformatics Institute (EMBL-EBI, Cambridge) where she worked as a Project and Team Coordinator and Principal Investigator in research data management.
Susanna moved to Oxford in October 2010 as Principal Investigator at the Oxford e-Research Centre, and in 2013 she was appointed to her current position of Associate Director. Since 2012 she is also a consultant for Nature Research Group at Springer Nature, and the founding editor of its Scientific Data journal.