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The main focus of our lab is to understand how cells detect and repair DNA damage induced by ionizing radiation and chemotherapeutic drugs. Of particular interest are the roles of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and Ataxia Telangiectasia Mutated (ATM) in the cellular response to DNA damage. A major goal is to use our knowledge of the DNA damage response to develop novel approaches to improve cancer treatment. We are currently exploring the use of poly ADP ribose polymerase (PARP) inhibitors to target ATM deficient cancers and the role of PI3 kinase in cisplatin resistance.
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论文共 238 篇作者统计合作学者相似作者
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Biochemical Society transactions (2023)
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Eli S. Williams, Rebekah Klingler, Brian Ponnaiya, Tanja Hardt, Evelin Schrock,Susan P. Lees-Miller,Katheryn Meek,Robert L. Ullrich,Susan M. Bailey
crossref(2023)
Science Advancesno. 22 (2023): eadg2838-eadg2838
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Juan P. Unfried,Mikel Marín-Baquero,Ángel Rivera-Calzada,Nerea Razquin, Eva M. Martín-Cuevas,Sara de Bragança,Clara Aicart-Ramos, Christopher McCoy,Laura Prats-Mari,Raquel Arribas-Bosacoma,Linda Lee,Stefano Caruso,
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Research Square (Research Square) (2022)
Faculty reviews (2022): 35
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