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Dr. Ambudkar and colleagues elucidate the role of ABC drug transporters in cancers that develop resistance to anti-cancer drugs. They facilitate the development of new therapeutic strategies to improve the efficiency of chemotherapy for cancer patients. Transition metal ion Forster resonance energy transfer, chemical crosslinking, directed mutagenesis, and molecular modeling techniques are used to understand the molecular mechanisms of polyspecificity, the catalytic cycle and drug transport. Monoclonal antibodies and various mutant variants are used to obtain high-resolution structures of P-glycoprotein (ABCB1). They also characterize the modulatory effect of targeted therapeutic tyrosine kinase inhibitors and non-toxic natural products to overcome ABC transporter-mediated drug resistance.
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Shinobu Ohnuma,Shoji Kokubo,Norihiko Sugisawa,Megumi Murakami, Yuuri Hatsuzawa,Minoru Kobayashi,Taiki Kajiwara, Hideyuki Suzuki,Hideaki Karasawa, Kazuhiro Watanabe,Takayuki Doi,Suresh V. Ambudkar,
Cancer Researchno. 6_Supplement (2024): 4674-4674
Drug Resistance Updates (2024): 101065-101065
Isadora da Silva Zanzarini,Diogo Henrique Kita, Gustavo Scheiffer, Kelly Karoline Dos Santos, Julia de Paula Dutra, Matteo Augusto Pastore,Fabiane Gomes de Moraes Rego,Geraldo Picheth,Suresh V Ambudkar, Luana Pulvirenti,Nunzio Cardullo,Vivian Rotuno Moure,
Bioorganic chemistry (2024): 107283-107283
Isadora da Silva Zanzarini,Diogo Henrique Kita, Gustavo Scheiffer, Kelly Karoline dos Santos,Julia de Paula Dutra, Matteo Augusto Pastore,Fabiane Gomes de Moraes Rego,Geraldo Picheth,Suresh V. Ambudkar,Luana Pulvirenti,Nunzio Cardullo,Vivian Rotuno Moure,
Bioorganic Chemistry (2024)
Zhi Shi,Amit K. Tiwari,Suneet Shukla,Robert W. Robey,Satyakam Singh, In-Wha Kim,Susan E. Bates, Xingxiang Peng,Ioana Abraham,Suresh V. Ambudkar,Tanaji T. Talele,Li-Wu Fu,
crossref(2023)
crossref(2023)
Yan-jun Mi,Yong-ju Liang,Hong-bing Huang,Hong-yun Zhao,Chung-Pu Wu,Fang Wang, Li-yang Tao,Chuan-zhao Zhang, Chun-Ling Dai,Amit K. Tiwari,Xiao-xu Ma, Kenneth Kin Wah To,
crossref(2023)
ACS Pharmacology & Translational Scienceno. 1 (2023): 161-175
MOLECULAR PHARMACEUTICSno. 6 (2023): 3249-3249
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