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个人简介
Dr. Rosenberg pioneered the first effective immunotherapies for patients with advanced cancer. His basic and clinical studies of interleukin-2 directly resulted in the approval of this immunotherapy by the US Food and Drug Administration for the treatment of patients with metastatic melanoma and renal cancer, many of whom remain disease-free over 25 years after treatment. His studies of cell transfer immunotherapy using tumor infiltrating lymphocytes (TIL) that resulted in durable complete remissions in patients with metastatic melanoma were the first to directly demonstrate the effective role of T lymphocyte in human cancer immunotherapy and the approach has now been applied to the treatment of patients with metastatic solid cancers. He pioneered the development of gene therapy and was the first to successfully insert foreign genes into humans. He was the first to demonstrate the clinical effectiveness of genetically engineered Chimeric Antigen Receptor (CAR) T-cells to mediate the regression of B-cell malignancies in humans, a treatment now approved by the FDA for widespread use. In recent work Dr. Rosenberg established new approaches for the application of immunotherapy to patients with a variety of common solid epithelial cancers by targeting the unique mutations present in the patient’s cancer.
研究兴趣
论文共 2196 篇作者统计合作学者相似作者
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Aaron J. Dinerman, Alexandra M. Gustafson,Ali T. Elsaadi,Donald White,David S. Schrump,Chuong D. Hoang,Jonathan M. Hernandez,Mei Li Kwong,James C. Yang,Stephanie Goff,Steven A. Rosenberg, Nicholas D. Klemen
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Surajit Sinha,Abir Panda,Zeribe Nwosu, Rodrigo Neves Das,Xu Ke, Elke van Beek, Alexander J. Rossi,Reed I. Ayabe,James McDonald,Michael M. Wach,Samantha Ruff, Priyanka P. Desai,
CANCER RESEARCHno. 2 (2024)
David A. Solomon,Jung-Sik Kim, Julia C. Cronin,Zita Sibenaller, Timothy Ryken,Steven A. Rosenberg,Habtom Ressom,Walter Jean,Darell Bigner,Hai Yan,Yardena Samuels,Todd Waldman
crossref(2023)
Blood (2023): 888
crossref(2023)
crossref(2023)
Praveen D. Chatani,Frank J. Lowery,Neilesh B. Parikh, Kyle Hitscherich,Rami Yossef,Victoria Hill,Jared J. Gartner,Biman C. Paria,Maria Florentin,Satyajit Ray,Alakesh Bera, Maria Parkhust,
Journal for ImmunoTherapy of Cancerno. 5 (2023): e006264-e006264
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arXiv (Cornell University) (2023)
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crossref(2023)
Hildegund C.J. Ertl,John Zaia,Steven A. Rosenberg,Carl H. June,Gianpietro Dotti,Jeffrey Kahn,Laurence J.N. Cooper, Jacqueline Corrigan-Curay,Scott E. Strome
crossref(2023)
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