McCarroll and the scientists in his lab use genetics, molecular biology, and novel approaches for single-cell analysis to reveal the ways in which genomes vary from person to person and the mechanisms by which such variation contributes to human disease. By applying new molecular and computational approaches to study the brain, he hopes to uncover the key molecular and cellular events in the development of schizophrenia and other brain illnesses. The hope is that such discoveries will lead to new, innovative therapies.