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Dr. Kahn’s research focuses on the role of the islet β-cell in diseases associated with disturbed glucose metabolism.
His basic science research revolves around the role of islet amyloid formation in the loss of β-cells and development of β-cell secretory dysfunction. As part of this work, he and his group have identified a number of islet proteins that have detrimental effects on the β-cell, including most recently the cholesterol transport protein Steroidogenic Acute Regulatory Protein (StAR). They have also observed that the innate immune system is activated by amyloid formation and are examining the role of necroptosis, an immune form of cell death, in the loss of β-cells. Their work also aims to find novel approaches to prevent islet amyloidogenesis, including the tissue plasminogen activator/plasmin system and synthetic peptides that interfere with amyloid formation.
His clinical research focuses on physiological studies of the mechanisms by which the β-cell adapts to changes in secretory demand, the importance of propeptide processing in the development of hyperglycemia, the role of central adiposity as a determinant of metabolic disease and the mechanisms responsible for hypoglycemia in patients with cystic fibrosis. In addition, he participates in and holds leadership positions in a number of major clinical trials related to type 2 diabetes including the Diabetes Prevention Program and its follow up the Diabetes Prevention Program Outcomes Study (DPP/DPPOS), Look AHEAD, Restoring Insulin Secretion Study (RISE) and Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).
His basic science research revolves around the role of islet amyloid formation in the loss of β-cells and development of β-cell secretory dysfunction. As part of this work, he and his group have identified a number of islet proteins that have detrimental effects on the β-cell, including most recently the cholesterol transport protein Steroidogenic Acute Regulatory Protein (StAR). They have also observed that the innate immune system is activated by amyloid formation and are examining the role of necroptosis, an immune form of cell death, in the loss of β-cells. Their work also aims to find novel approaches to prevent islet amyloidogenesis, including the tissue plasminogen activator/plasmin system and synthetic peptides that interfere with amyloid formation.
His clinical research focuses on physiological studies of the mechanisms by which the β-cell adapts to changes in secretory demand, the importance of propeptide processing in the development of hyperglycemia, the role of central adiposity as a determinant of metabolic disease and the mechanisms responsible for hypoglycemia in patients with cystic fibrosis. In addition, he participates in and holds leadership positions in a number of major clinical trials related to type 2 diabetes including the Diabetes Prevention Program and its follow up the Diabetes Prevention Program Outcomes Study (DPP/DPPOS), Look AHEAD, Restoring Insulin Secretion Study (RISE) and Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).
Research Interests
Papers共 807 篇Author StatisticsCo-AuthorSimilar Experts
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Rebecca Palmer,Rebecca H. Neiberg,Kristen M. Beavers,Steven E. Kahn,Denise K. Houston,Lynne Wagenknecht,Karen C. Johnson, Henry J. Pownall,Mark A. Espeland, Action Hlth Diabet Look AHEAD Aging Study Grp
OBESITY (2025)
Kristin A Sauter,Gabriela M Webb,Lindsay Bader,Craig N Kreklywich,Diana L Takahashi, Cicely Zaro, Casey M McGuire,Anne D Lewis,Lois M A Colgin,Melissa A Kirigiti, Hannah Blomenkamp,Cleiton Pessoa, Matthew Humkey,Jesse Hulahan, Madeleine Sleeman, Robert C Zweig, Sarah Thomas,Archana Thomas,Lina Gao,Alec J Hirsch, Mayaan Levy, Sara R Cherry,Steven E Kahn,Mark K Slifka,Daniel N Streblow,Jonah B Sacha,Paul Kievit,Charles T Roberts
bioRxiv the preprint server for biology (2025)
Mikhail N. Kosiborod,John Deanfield,Richard Pratley,Barry A. Borlaug,Javed Butler,Melanie J. Davies,Scott S. Emerson,Steven E. Kahn,Dalane W. Kitzman,Ildiko Lingvay,Kenneth W. Mahaffey,Mark C. Petrie,Jorge Plutzky,Soren Rasmussen, Cecilia Ronnback,Sanjiv J. Shah,Subodh Verma,Peter E. Weeke,A. Michael Lincoff
LANCETno. 10456 (2024): 949-961
DIABETES CAREno. 4 (2024): 580-588
Diabetes Careno. 4 (2024): 571-579
Ildiko Lingvay,Robert Kushner,John Deanfield, Signe Stensen, Rafael Bravo, Morten Rix Hansen, Paul Mathew Brown,G. Kees Hovingh,A. Michael Lincoff,Steven Kahn,Donna Ryan
OBESITY (2024): 25-25
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Diabetes careno. 9 (2024): 1509-1510
Noyonika Mukherjee,Christopher J. Contreras,Li Lin, Kaitlyn A. Colglazier, Egan G. Mather,Michael A. Kalwat,Nathalie Esser,Steven E. Kahn,Andrew T. Templin
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Author Statistics
#Papers: 807
#Citation: 80596
H-Index: 117
G-Index: 278
Sociability: 8
Diversity: 3
Activity: 181
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