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Professor Ley’s group researches the regulation and function of specific NF-kB and MAP kinase signalling pathways in inflammation and immunity. One of his key discoveries was the demonstration that activation of the MAP 3-kinase TPL-2 is controlled by the IkB kinase (IKK) complex. This work shows that activation of the ERK1 and ERK2 MAP kinases is directly linked to activation of NF-kB transcription factors during inflammatory responses. He has also shown that IKK-induced proteolysis of NF-kB1 p105 has essential cell-intrinsic roles in T and B cells in adaptive immune responses.
Professor Ley’s group is currently investigating how TPL-2 signalling regulates transcription in inflammation and the function of the TPL-2-associated protein ABIN-2 in airway allergic responses. In a new area of research for the laboratory (done in collaboration with Anne Bowcock at Mt. Sinai, New York, USA), his group is also researching how the adaptor protein CARD14 activates NF-kB to trigger inflammation in the skin. Mutations in the gene encoding CARD14 lead to a high risk of developing psoriasis and psoriatic arthritis.
Professor Ley’s group is currently investigating how TPL-2 signalling regulates transcription in inflammation and the function of the TPL-2-associated protein ABIN-2 in airway allergic responses. In a new area of research for the laboratory (done in collaboration with Anne Bowcock at Mt. Sinai, New York, USA), his group is also researching how the adaptor protein CARD14 activates NF-kB to trigger inflammation in the skin. Mutations in the gene encoding CARD14 lead to a high risk of developing psoriasis and psoriatic arthritis.
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Simon Rousseau, Matoula Papoutsopoulou,Antony Symons, Dorthe Cook,John M. Lucocq,Alan R. Prescott,Anne O'Garra,Steven C. Ley,Philip Cohen
Journal of Cell Scienceno. 21 (2022)
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biorxiv(2022)
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