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The major focus of the lab is on the molecular basis of prostate cancer development and progression. The androgen receptor, which is a member of the steroid hormone receptor superfamily, plays a major role in prostate cancer. We have identified mutations in the androgen receptor that contribute to prostate cancer progression and are characterizing androgen receptor interacting proteins. We have also determined that the platelet derived growth factor receptor contributes to prostate cancer and are attempting to define other important growth factor-receptor interactions that may be useful therapeutic targets. Finally, efforts are underway to develop murine transgenic and gene knockout models of PCa. A second interest in the lab is a novel T cell population termed NK T cells and the MHC class I-like CD1d protein they recognize. These cells appear to have an important immunoregulatory function and we are determining the role they play in viral infections and anti-tumor
研究兴趣
论文共 460 篇作者统计合作学者相似作者
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Communications biologyno. 1 (2024): 25-25
Dong Han,Maryam Labaf,Yawei Zhao,Jude Owiredu,Songqi Zhang, Krishna Patel, Kavita Venkataramani,Jocelyn S. Steinfeld,Wanting Han,Muqing Li,Mingyu Liu,Zifeng Wang,
Journal of Clinical Investigation (2024)
bioRxiv : the preprint server for biology (2024)
Juan M Jimenez-Vacas,Daniel Westaby,Ines Figueiredo,Jan Rekowski, Claire Pettinger,Bora Gurel,Denisa Bogdan,Lorenzo Buroni,Antje Neeb, Ana Padilha, Joe Taylor, Wanting Zeng,
Endocrine Abstracts (2024)
CANCER RESEARCHno. 11 (2023)
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Fen Ma,Seiji Arai, Keshan Wang,Carla Calagua, Amanda R. Yuan,Larysa Poluben, Zhongkai Gu,Joshua W. Russo,David J. Einstein,Huihui Ye,Meng Xiao He,Yu Liu,
crossref(2023)
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Cancer Researchno. 11_Supplement (2023): A019-A019
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