基本信息
浏览量:155
职业迁徙
个人简介
A major focus of my work has been the endogenous cannabinoid system, with particular attention on inflammation and pain. In this context, three of my most highly-cited publications investigated vasoactivity of anandamide (the first identified endocannabinoid), neuroprotection via cannabinoid activation of PPARα and the regulation of dopaminergic neurotransmission in the striatum. My central area of research concerns the pharmacology and biochemistry of G protein-coupled receptors (in particular, cannabinoid, adenosine and glutamate) in the CNS and peripheral tissues. I am interested in how activation of one of these classes of receptor leads to modification of the response to other receptor classes (cross-talk), as well as how different ligands can provoke different signalling profiles at the same receptor (agonist bias).
An additional focus of my research has been an investigation of enzymes (particularly those involved in turnover of endocannabinoids, hydrogen sulphide and cyclic nucleotides), as convergence points for signalling cross-talk, as well as quantifying enzyme activities ex vivo, for example, in pathological conditions or following drug exposure. I also investigate key enzymes as targets for drug discovery, generating high-throughput assays in vitro. A third area of research is the role of mitochondria in cell survival and/or toxicity following drug exposure or under substrate-limited conditions.
An additional focus of my research has been an investigation of enzymes (particularly those involved in turnover of endocannabinoids, hydrogen sulphide and cyclic nucleotides), as convergence points for signalling cross-talk, as well as quantifying enzyme activities ex vivo, for example, in pathological conditions or following drug exposure. I also investigate key enzymes as targets for drug discovery, generating high-throughput assays in vitro. A third area of research is the role of mitochondria in cell survival and/or toxicity following drug exposure or under substrate-limited conditions.
研究兴趣
论文共 609 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Yuanfei Zhao,Leigh Nicholson, Hannah Wang, Yi Wen Qian,Wayne J. Hawthorne,Elvira Jimenez-Vera,Brian S. Gloss,Joey Lai,Adwin Thomas,Yi Vee Chew,Heather Burns,Geoff Y. Zhang,
JCI INSIGHTno. 6 (2024)
Shi-Ting Wu, Yu Feng,Renhua Song, Yanmiao Qi,Lin Li, Dongbo Lu,Yixuan Wang, Wenrun Wu,Angela Morgan,Xiaohong Wang,Yin Xia,Renjing Liu,
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2024)
British Journal of Pharmacologyno. S2 (2023): S374-S469
British Journal of Pharmacologyno. S2 (2023): S23-S144
Nucleic acids researchno. D1 (2023): D1438-D1449
British Journal of Pharmacologyno. 17 (2023): 2193-2195
British Journal of Pharmacologyno. S2 (2023): S145-S222
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn