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个人简介
His research focuses on biomarker and drug development for prevention and early treatment of Alzheimer’s disease (AD). During his time at Brown, the Butler Hospital Memory and Aging Program (MAP) has become an internationally recognized center for clinical research in Alzheimer’s disease. The MAP has helped pioneer the use of PET ligands for amyloid and tau to study the evolution of AD pathophysiology in autosomal dominant and sporadic AD. The program has had a lead role in testing targeted treatments, such as BACE inhibitors and monoclonal antibodies, alone and in combination, to lower amyloid plaques and neurofibrillary tangles, as well as novel approaches, such as deep brain stimulation, to slow the progression of AD. The MAP is developing new strategies using genetic testing and brain imaging to recruit cognitively normal elderly at increased risk for AD for prevention studies.
研究兴趣
论文共 372 篇作者统计合作学者相似作者
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Nathaniel A Chin, Debra Dinsmore, Tony Gonzales, Betsy Groves,Stephanie Houston, Dan Johnson, DeLois Johnson, Julia Napolitano, Allan Ropper,Stephen Salloway, Rob Sutherland, Lori Weiss,
The New England journal of medicineno. 12 (2024): e29-e29
Nathaniel A Chin, Debra Dinsmore, Tony Gonzales, Betsy Groves,Stephanie Houston, Dan Johnson, DeLois Johnson, Julia Napolitano,Allan Ropper,Stephen Salloway, Rob Sutherland, Lori Weiss,
New England Journal of Medicineno. 12 (2024): e29-e29
Nathaniel A Chin, Debra Dinsmore, Tony Gonzales, Betsy Groves, DeLois Johnson, Julia Napolitano, Allan Ropper,Stephen Salloway, Lori Weiss
New England Journal of Medicineno. 10 (2024): e22-e22
Stephanie Doering,Austin McCullough,Brian A. Gordon,Charles D. Chen,Nicole McKay,Diana Hobbs,Sarah Keefe,Shaney Flores, Jalen Scott, Hunter Smith, Stephen Jarman, Kelley Jackson,
EBioMedicine (2024): 105080
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Maria Soto,P. Rosenberg, C. Ballard,B. Vellas, D. Miller,S. Gauthier,M. C. Carrillo, C. Lyketsos, Z. Ismail,Susan Abushakra, Mohammad Afshar, Sam Agus,
Michael Geschwind,Jose Biller, Jamie Elliott, Suman Jayadev,Stephen Salloway,Jose Gutierrez,Sudha Seshadri,Jennifer Majersik,Karen Orjuela,David Liebeskind,Helmi Lutsep, Ihab Hajjar,
Alzheimer's & dementia : the journal of the Alzheimer's Association (2023): S74-S88
JAMA neurology (2023)
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