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Dr Keyse’s research is focussed on the regulation of signal transduction through the mitogen-activated protein kinase (MAPK) pathways in mammalian cells. His laboratory was amongst the first to isolate and characterise DUSP1/MKP-1, the prototypic member of a family of dual-specificity (Thr/Tyr) protein phosphatases, as a gene that is highly inducible in response to oxidative stress. He went on to demonstrate that DUSP-1/MKP-1 can specifically dephosphorylate and inactivate MAPKs in mammalian cells, thus identifying DUSP1 and closely related enzymes as dual-specificity MAPK phosphatases or MKPs. Subsequent work has concentrated on the mechanisms by which these enzymes are able to recognise and differentially inactivate distinct MAPK isoforms and has included structural and biochemical studies, which have revealed important aspects of catalytic mechanism. More recently, he has employed developmental, transgenic and mouse knockout models to dissect the complexities of MAPK regulation by the MKPs and the roles of these enzymes in regulating the biological outcome of MAPK signalling both in normal cells and in human diseases including cancer.
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Gianluigi Nocera,Adrien Vaquié,Nadège Hertzog,Katharina Steil, Santiago Luis Cañón Duque, Johannes Miedema,Cansu Bagin,Margaryta Tevosian,Beat Lutz,Azadeh Sharifi-Aghili, Katharina Hegner, Doris Vollmer,
biorxiv(2023)
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Gianluigi Nocera,Adrien Vaquié,Nadège Hertzog,Katharina Steil, Sandra Duqué, Johannes Miedema,Cansu Bagin,Margaryta Tevosian,Beat Lutz,Azadeh Sharifi-Aghili, Katharina Hegner, Doris Vollmer,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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