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个人简介
Stephen Weiss's research efforts have long focused on the mechanisms used by white blood cells, endothelial cells and cancer cells to remodel tissue structure during events ranging from inflammatory disease and angiogenesis to cancer. His highly cited works on the role of metalloproteinases in regulating these pathologic events have appeared consistently in top-ranked journals such as Science, Nature, Genes & Development, the Journal of Cell Biology, the Journal of Experimental Medicine, the Proceedings of the National Academy of Sciences, Developmental Cell and Cell. Most recently, Dr. Weiss’ characterization of a family of membrane-anchored enzymes, the MT-MMPs, lends credence to his novel hypothesis that these proteases act as master switches in controlling key functions of normal and neoplastic cell behavior in vivo.
When Weiss first embarked onto his current path of research, i.e., studying the mechanisms of a group of proteinases - he calls their "molecular scissors" - his lab had been working on oxygen radicals, highly reactive small molecules "that nobody would think would ever be purposely generated in a biological system." One of the downstream products of oxygen radicals is hypochlorous acid, which both kills microorganisms and activates a latent collagenase secreted by white blood cells that can cleave their way through connective tissues, an action that he likens to removing the scissors' sheath so they can begin to cut.
研究兴趣
论文共 311 篇作者统计合作学者相似作者
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Xiaoxiao Liu,Baolei Li,Shuyun Wang, Erge Zhang, Megan Schultz,Marlin Touma, Andre Monteiro Da Rocha,Sylvia M Evans,Anne Eichmann,Todd Herron,Ruizhen Chen, Dingding Xiong,
Circulation research (2024)
JOURNAL OF BONE AND MINERAL RESEARCH (2023): 72-73
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Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2023)
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Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2023)
Lingxin Zhu, Yi Tang, Xiao-Yan Li,Samuel A Kerk,Costas A Lyssiotis, Xiaoyue Sun,Zijun Wang,Jung-Sun Cho, Jun Ma,Stephen J Weiss
Nature communicationsno. 1 (2023): 4271-14
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Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2023)
Plastic and reconstructive surgery. Global openno. 5S (2023): 7-8
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Carol Wise,Anas Khanshour, Hao Yu,Aki Ushiki, Xiao-Yan Li,Nao Otomo,Yoshinao Koike, Elisabet Einarsdotti, Felix Fan,Lilian Antunes, Rory Sheng,Yichi Zhang,
JOURNAL OF BONE AND MINERAL RESEARCH (2023): 66-66
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