基本信息
浏览量:2
职业迁徙
个人简介
Dr. Stephen Benkovic is known for his major contributions that have initiated or shaped our understanding of biological processes. Benkovic was the first to hypothesize that conformational changes outside the enzyme’s active site were necessary for achieving maximal catalysis. This is beautifully illustrated by his studies on dihydrofolate reductase (DHFR). Benkovic showed how multi-enzyme complexes are assembled to achieve specificity and function and where several activities are present how they are mediated. This was accomplished in his studies on DNA replication that featured assembly, disassembly and function of the T4 replisome that coordinated DNA replication. Benkovic discovered the first example of a reversible metabolon, the purinosome, that only assembles in response to cellular demands and has demonstrated that the purinosome acts temporarily and spatially to form and deliver needed metabolites to cellular constituents.
研究兴趣
论文共 269 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Joost Clerx, Stijn F. M. van Dongen,Kasper Nørgaard,Michael A. Trakselis,Scott W. Nelson,Stephen J. Benkovic,Alan E. Rowan,Roeland J. M. Nolte
semanticscholar(2017)
引用0浏览0引用
0
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn