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To understand the genetic basis of heart size (which after age is the single most important cardiovascular risk factor), I initiated series of breeding studies in rats in 1989. This resulted in the first identification by genome wide scanning of a gene that controls heart size independent of blood pressure. The breeding continued to produce a new strain of rat - Hypertrophic Heart Rats (HHR) - that has normal blood pressure but a big heart and develops heart failure. Our recent studies with Prof Leanne Delbridge here at the University of Melbourne and Prof Fadi Charchar at the University of Ballarat are making major headway into understanding the pathophysiology of cardiac hypertrophy and heart failure from the molecular, cellular and whole organ perspective.
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论文共 316 篇作者统计合作学者相似作者
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Leah E Cahill,Rachel A Warren,Allie S Carew,Andrew P Levy,John Sapp, Michelle Samuel,Elizabeth Selvin, Samantha K Lavallée,Neil Poulter,Michel Marre,Stephen Harrap,Giuseppe Mancia,
Sean Byars,Priscilla Prestes,Vara Suphapimol, Nathan De Vries, Mariana Del Rosso Le Melo,Michelle Maier,Nilesh Samani, Jennifer Wilkinson Berka,Andrew Allen,Fadi Charchar,Stephen Harrap
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Stephen Harrap,Sean G. Byars,Priscilla Prestes, Vara Suphapimol, Fumihiko Takeuchi, Nathan De Vries,Michelle Maier, Mariana Melo, David J. Balding,Nilesh J. Samani,Andrew M. Allen,Norihiro Kato,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2022): S77-S78
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Clinical Journal of The American Society of Nephrologyno. 8 (2022): 1139-1149
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