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Sensation of environmental stimuli, thought, learning, memory, and other aspects of neuronal communication, hormone secretion and movement all rely on cellular electrical signals. We study life’s electrical system from a molecular and biophysical perspective. The focus of the laboratory is on ion channels, transporters and their regulatory complexes that form gated pathways for ionic traffic across cell membranes. We aim to discover how these membrane proteins work at a detailed mechanistic level and what they do in a biological context. To this end, we utilize a range of approaches including structural biology (X-ray crystallography and cryo-EM), electrophysiology, biophysics, biochemistry, pharmacology and imaging. Our goals are to understand the molecular basis of sensory transduction and electrical signaling and to lay the groundwork for development of new approaches to promoting health and treating disease.
Sensation of environmental stimuli, thought, learning, memory, and other aspects of neuronal communication, hormone secretion and movement all rely on cellular electrical signals. We study life’s electrical system from a molecular and biophysical perspective. The focus of the laboratory is on ion channels, transporters and their regulatory complexes that form gated pathways for ionic traffic across cell membranes. We aim to discover how these membrane proteins work at a detailed mechanistic level and what they do in a biological context. To this end, we utilize a range of approaches including structural biology (X-ray crystallography and cryo-EM), electrophysiology, biophysics, biochemistry, pharmacology and imaging. Our goals are to understand the molecular basis of sensory transduction and electrical signaling and to lay the groundwork for development of new approaches to promoting health and treating disease.
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论文共 47 篇作者统计合作学者相似作者
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Nature communicationsno. 1 (2024): 3142-3142
Susheel K. Gunasekar,Litao Xie,Ashutosh Kumar,Juan Hong,Pratik R. Chheda,Chen Kang,David M. Kern,Chau My-Ta,Joshua Maurer, John Heebink, Eva E. Gerber,Wojciech J. Grzesik,
biorxiv(2022)
Nature Communicationsno. 1 (2022)
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