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个人简介
I have extensive experience in the development and preclinical testing of engineered cell therapies and signal transduction inhibitors in leukemia, in pediatric trials using both, and in the manufacture and use of cellular therapeutics in preclinical, GMP, and clinical trial settings. I currently lead/have led most of the CTL019 (CD19 CAR) clinical trials at CHOP, in the US, and globally. Our group at CHOP and U Penn has led the field of highly active CAR T cell therapy, culminating in the FDA approval of CTL019/tisagenlecleucel as Kymriah, the first CAR T product ever approved, and the first gene therapy approved in the US. Over the last 10 years, our team has built a one of the most capable cell therapy groups in the world at both CHOP and U Penn, which can implement cell therapy trials with GMP cell manufacturing (Penn CVPF), at registrational level, with full regulatory support, and unmatched clinical implementation. Our work now encompasses engineered cell therapies for non-malignant diseases, including sickle cell disease. I am committed to improving outcomes for children who undergo cell therapies including malignant and non-malignant engineered cell therapies and hematopoietic cell transplantation. The goal - changing the standard of care.
研究兴趣
论文共 649 篇作者统计合作学者相似作者
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Caitlin W. Elgarten, Stephanie Heidemann,Jason L. Freedman,Stephan A. Grupp, Patricia Hankins,Stephan Kadauke,Yimei Li, Barbara McGlynn,Timothy S. Olson,Yongping Wang,Lisa Wray,Lei Wang,
Transplantation and Cellular Therapyno. 2 (2024): S9-S10
Transplantation and Cellular Therapyno. 2 (2024): S52-S53
Transplantation and Cellular Therapyno. 2 (2024): S236
Alexander E Doan, Katherine P Mueller, Andy Y Chen, Geoffrey T Rouin, Yingshi Chen,Bence Daniel,John Lattin, Martina Markovska, Brett Mozarsky, Jose Arias-Umana,Robert Hapke,In-Young Jung,
Nora M. Gibson,Caitlin W. Elgarten,Joseph H. Oved,Lisa Wray,Jason L. Freedman,Yongping Wang,Stephan Kadauke, Patricia Hankins,Peter Nicholas, Elizabeth Worster,Janet L. Kwiatkowski,Stephan A. Grupp,
Transplantation and Cellular Therapyno. 2 (2024): S301-S302
Rakesh Awasthi,Edward Waldron,Stephan A. Grupp, Mike A. Pulsipher,Peter Bader, Stephen J. Schuster,Richard T. Maziarz,Edmund K. Waller,Ulrich Jager,Catherine Thieblemont,Martin Dreyling,Nathan H. Fowler,
Transplantation and Cellular Therapyno. 2 (2024): S198-S199
Blood advances (2024)
Roni Devassy, Ms. Victoria Collier, Mrs. Patricia Hankins, Richard S Hanna, Ezra Porter, Alexander J Peters,Stephan A. Grupp,Stephan Kadauke
Transplantation and Cellular Therapyno. 2 (2024): S442
Ali Farrokhi, Tanmaya Atre,Jenna Rever,Mario Fidanza, Wendy Duey, Samuel Salitra, Junia Myung,Meiyun Guo,Sumin Jo,Anuli Uzozie, Fatemeh Baharvand,Nina Rolf,
Leukemiapp.1-12, (2024)
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