基本信息
浏览量:79
职业迁徙
个人简介
Our lab has developed a battery of monoclonal ant-myosin heavy chain antibodies that are widely used to distinguish muscle fiber types in rodent and human skeletal muscle. We have identified a distinct type 2X myosin isoform and shown that this myosin is coded by the MYH1 gene. More recently, we have revealed novel aspects of mitochondrial specialization in skeletal muscle fibers by single muscle fiber proteomics. Using the same approach we found that human fast and slow muscle fibers undergo strikingly different, in some case opposite, changes during aging, which are masked in whole muscle analyses.
We have developed a novel approach based on transfection of regenerating and adult skeletal muscle to explore the signaling pathways controlling the muscle phenotype, thus revealing the role of the calcineurin-NFAT pathway and the Akt-mTOR pathway in muscle fiber type and size, respectively. More recently, we have identified the MRF4-MEF2 axis as a major pathway regulating muscle hypertrophy. Finally, we have shown that the muscle phenotype undergoes major circadian changes that are in part controlled by the intrinsic muscle clock. In particular, the muscle clock regulated glucose uptake and oxidation, thus anticipating the metabolic changes associated with the transition from the rest/fasting phase to the active/feeding phase of the day/night cycle. Ongoing studies aim to determine how the intrinsic muscle clock affects lipid metabolism and the muscle response to adrenergic stimulation.
We have developed a novel approach based on transfection of regenerating and adult skeletal muscle to explore the signaling pathways controlling the muscle phenotype, thus revealing the role of the calcineurin-NFAT pathway and the Akt-mTOR pathway in muscle fiber type and size, respectively. More recently, we have identified the MRF4-MEF2 axis as a major pathway regulating muscle hypertrophy. Finally, we have shown that the muscle phenotype undergoes major circadian changes that are in part controlled by the intrinsic muscle clock. In particular, the muscle clock regulated glucose uptake and oxidation, thus anticipating the metabolic changes associated with the transition from the rest/fasting phase to the active/feeding phase of the day/night cycle. Ongoing studies aim to determine how the intrinsic muscle clock affects lipid metabolism and the muscle response to adrenergic stimulation.
研究兴趣
论文共 45 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
mag(2015)
引用23浏览0引用
23
0
mag(2015)
引用22浏览0引用
22
0
mag(2015)
引用24浏览0引用
24
0
mag(2015)
引用23浏览0引用
23
0
mag(2014)
引用24浏览0引用
24
0
mag(2014)
引用23浏览0引用
23
0
mag(2013)
引用23浏览0引用
23
0
mag(2012)
引用26浏览0引用
26
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn