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职业迁徙
个人简介
My laboratory is interested in host cell interactions and pathogenesis of emerging viruses and primate herpesviruses. One focus is on viral entry into cells. We could show that SARS-CoV-2 uses the ACE2 protein as receptor and the cellular protease TMPRSS2 for spike protein activation. Further, we provided evidence that lung cell entry of SARS-CoV-2 is TMPRSS2-dependent and largely insensitive against chloroquine. In addition, we showed that the Beta, Gamma and, particularly, the Omicron variant of SARS-CoV-2 evade antibody-mediated neutralization. At present, our focus is on BA.2.12.1 and BA.4/BA.5. In the context of herpesviruses, we want to understand why Herpes B Virus (macacine alphaherpesvirus 1) but not closely related herpesviruses causes severe disease in humans. For this, we are generating recombinant viruses and new cell systems. Finally, we offer diagnostics for virus infections of non-human primates, including colony screening.
研究兴趣
论文共 328 篇作者统计合作学者相似作者
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Rüdiger Groß, Hanna Reßin,Pascal von Maltitz, Dan Albers, Laura Schneider, Hanna Bley,Markus Hoffmann,Mirko Cortese,Dhanu Gupta, Miriam Deniz,Jae-Yeon Choi,Jenny Jansen,
Nature Microbiologypp.1-17, (2024)
Matthias Bruhn,Maureen Obara, Abdus Salam,Bibiana Costa, Annett Ziegler,Inken Waltl,Andreas Pavlou,Markus Hoffmann,Theresa Graalmann,Stefan Pöhlmann,Axel Schambach,Ulrich Kalinke
Philipp Flury, Julian Breidenbach,Nadine Krueger,Rabea Voget,Laura Schaekel, Yaoyao Si, Vesa Krasniqi, Sara Calistri, Matthias Olfert, Katharina Sylvester,Cheila Rocha, Raphael Ditzinger,
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCEno. 2 (2024): 493-514
Metodi Stankov,Markus Hoffmann,Rodrigo Gutierrez Jauregui,Anne Cossmann,Gema Morillas Ramos, Theresa Graalmann, Emily Jo Winter,Michaela Friedrichsen,Inga Ravens, Tamara Ilievska,Jasmin Ristenpart,Anja Schimrock,
LANCET INFECTIOUS DISEASESno. 1 (2024): e1-e3
crossref(2024)
Najat Bdeir, Tatjana Lüddecke,Henrike Maaß,Stefan Schmelz,Henning Jacobsen,Kristin Metzdorf, Anne Cossmann, Metodi V. Stankov,Markus Hoffmann,Stefan Pöhlmann,Wulf Blankenfeldt, Alexandra Dopfner-Jablonka,
medrxiv(2024)
Philipp Flury,Julian Breidenbach,Nadine Krüger,Rabea Voget,Laura Schäkel, Yaoyao Si, Vesa Krasniqi, Sara Calistri, Matthias Olfert,Katharina Sylvester,Cheila Rocha, Raphael Ditzinger,
ACS pharmacology & translational scienceno. 4 (2024): 1195-1196
Bernardo R. Oliveira,Inga Nehlmeier,Amy Madeleine Kempf,Vaishnavi Venugopalan,Maren Rehders, Marianne E.P. Ceniza, Pedro A.de T.P.V. Cavalcanti,Markus Hoffmann,Stefan Pöhlmann,Klaudia Brix
Biochimie (2024)
biorxiv(2024)
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