基本信息
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职业迁徙
个人简介
His research focuses on understanding how matrix proteins control mineralization in enamel and dentin. Current approaches include:
Remineralization of Dentin Caries Lesions: Anionic polymers, like Poly-Aspartic Acid, are used to induce intrafibrillar mineral within collagen fibrils. This project attempts to recover lost dental tissue function by a mineralization process, (see, Burwell et al. PLOS-One 2011).
Mimicking Enamel Formation In-Vitro: Our recent studies in the lab have shown that amelogenin can self-assemble into ribbons which self-align and form an organic matrix mimicking the organization of apatite nanofibers in dental enamel. In this project we attempt to induce apatite crystallization on amelogenin templates to obtain materials similar to enamel (Martinez-Avila et al., Biomacromolecules 2012).
Micropatterned Porous Membranes for Dental Tissue Synthesis: In this project we designed a variety of porous membranes that enable the precise positioning of cells thus facilitating cellular organization similar to odontoblasts at the pulpal wall. We study the potential of these membranes for in-vitro synthesis of dentin and enamel using dental stem cells, embryonic stem cell and iPS cells.
Awards and Honors
NIH/NIDCR 2016 2021 R01-DE25709 Amyloids in Enamel Development R01-DE25709 Amyloids in Enamel Development, NIH/NIDCR, 2016-2021
NIH/NIDCR 2013 2015 R21-DE023422 A New Concept of Amelogenin-Guided Mineralization in Enamel R21-DE023422 A New Concept of Amelogenin-Guided Mineralization in Enamel, NIH/NIDCR, 2013-2015
NIH/NIDCR 2012 2017 RO1-DE16849 Dentin Structure, Demineralization and Remineralization RO1-DE16849 Dentin Structure, Demineralization and Remineralization, NIH/NIDCR, 2012-2017
NIH/NIDCR 2012 2014 R21DE022634 Mimicking the Dentin-Pulp Complex In-Vitro R21DE022634 Mimicking the Dentin-Pulp Complex In-Vitro, NIH/NIDCR, 2012-2014
NIH/NIDCR 2010 2015 RO1 DE 015821 Amelogenin degradation by MMP-20 in enamel (PI Wu Li) RO1 DE 015821 Amelogenin degradation by MMP-20 in enamel (PI Wu Li), NIH/NIDCR, 2010-2015
Remineralization of Dentin Caries Lesions: Anionic polymers, like Poly-Aspartic Acid, are used to induce intrafibrillar mineral within collagen fibrils. This project attempts to recover lost dental tissue function by a mineralization process, (see, Burwell et al. PLOS-One 2011).
Mimicking Enamel Formation In-Vitro: Our recent studies in the lab have shown that amelogenin can self-assemble into ribbons which self-align and form an organic matrix mimicking the organization of apatite nanofibers in dental enamel. In this project we attempt to induce apatite crystallization on amelogenin templates to obtain materials similar to enamel (Martinez-Avila et al., Biomacromolecules 2012).
Micropatterned Porous Membranes for Dental Tissue Synthesis: In this project we designed a variety of porous membranes that enable the precise positioning of cells thus facilitating cellular organization similar to odontoblasts at the pulpal wall. We study the potential of these membranes for in-vitro synthesis of dentin and enamel using dental stem cells, embryonic stem cell and iPS cells.
Awards and Honors
NIH/NIDCR 2016 2021 R01-DE25709 Amyloids in Enamel Development R01-DE25709 Amyloids in Enamel Development, NIH/NIDCR, 2016-2021
NIH/NIDCR 2013 2015 R21-DE023422 A New Concept of Amelogenin-Guided Mineralization in Enamel R21-DE023422 A New Concept of Amelogenin-Guided Mineralization in Enamel, NIH/NIDCR, 2013-2015
NIH/NIDCR 2012 2017 RO1-DE16849 Dentin Structure, Demineralization and Remineralization RO1-DE16849 Dentin Structure, Demineralization and Remineralization, NIH/NIDCR, 2012-2017
NIH/NIDCR 2012 2014 R21DE022634 Mimicking the Dentin-Pulp Complex In-Vitro R21DE022634 Mimicking the Dentin-Pulp Complex In-Vitro, NIH/NIDCR, 2012-2014
NIH/NIDCR 2010 2015 RO1 DE 015821 Amelogenin degradation by MMP-20 in enamel (PI Wu Li) RO1 DE 015821 Amelogenin degradation by MMP-20 in enamel (PI Wu Li), NIH/NIDCR, 2010-2015
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Karen A. Schulze, Noëlle M. Santucci, Bina Surti,Stefan Habelitz,Mouchumi Bhattacharyya, Warden Noble
Oralno. 1 (2024): 101-112
FRONTIERS IN PHYSIOLOGY (2023)
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Fernanda Furuse Ventura dos Santos,Stefan Habelitz,Fabio Dupart Nascimento,Victor Elias Arana-Chavez,Roberto Ruggiero Braga
JOURNAL OF FUNCTIONAL BIOMATERIALSno. 11 (2023): 537-537
NANO LETTERSno. 10 (2023): 4290-4297
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