基本信息
浏览量:3
职业迁徙
个人简介
Clinical Expertise
Dr. Riddell is an expert in using hematopoietic (blood-forming) stem cell transplantation (HCT) to treat patients with leukemias, lymphomas and other blood-related cancers, and in treating graft-versus-host disease (GVHD) that can occur when a donor’s immune T cells attack normal tissues as well as the malignancy. Based on his extensive clinical experience and laboratory investigations, Dr. Riddell has developed innovative therapies that use T cells to treat various viral infections and cancers. He was the principal investigator on the first human trial of transferred therapeutic T cells, to prevent dangerous cytomegalovirus infections after HCT, and on four subsequent clinical trials of ‘adoptive’ T cell therapy, including the first using leukemia-reactive T cells to treat relapsed leukemia post-transplant and the first using CAR-engineered T cells of defined subset composition.
Research Focus
Dr. Riddell’s early studies demonstrated the potential to augment T cell immunity by the adoptive transfer of antigen-specific T cells and uncovered mechanisms by which virally-infected cells evade immune recognition. These findings provided insights into similar mechanisms that tumors use to escape T cell immunity and that might be therapeutically targeted to improve patient outcomes. More recently, the Riddell team identified the subset of T cells that can best survive and function after transfer to patients and found that using clearly defined combinations of T-cell types can make the therapy even more effective. They have developed critical techniques for the isolation, expansion, genetic modification and reinfusion of therapeutic T cells, and for monitoring patient safety as well as T cell persistence, migration and function post-infusion. Many of these powerful methods are now broadly used in developing adoptive immunotherapies, including state-of-the-art ways to identify the tumor antigens recognized by T cells and to rapidly multiply the number of disease-fighting T cells.
研究兴趣
论文共 289 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Erica T. Goddard,Miles H. Linde,Shivani Srivastava, Grant Klug,Tamer B. Shabaneh, Santino Iannone,Candice A. Grzelak,Sydney Marsh,Alessandra I. Riggio, Ryann E. Shor,Ian L. Linde, Marissa Guerrero,
BLOOD ADVANCESno. 2 (2024): 453-467
Carla A. Jaeger-Ruckstuhl, Yun Lo, Elena Fulton,Olivia G. Waltner,Tamer B. Shabaneh,Sylvain Simon, Pranav V. Muthuraman,Colin E. Correnti,Oliver J. Newsom,Ian A. Engstrom,Sami B. Kanaan,Shruti S. Bhise,
Tamer Basel Shabaneh,Andrew R Stevens,Sylvia M Stull, Kristen R Shimp,Brandon W Seaton,Ekram A Gad,Carla A Jaeger-Ruckstuhl,Sylvain Simon,Amanda L Koehne,Jason P Price,James M Olson, Benjamin G Hoffstrom,
Journal for ImmunoTherapy of Cancerno. 2 (2024)
Mortimer Svec, Sarah Doetsch, Linda Warmuth, Manuel Trebo, Simon Fraessle,Stanley R. Riddell,Ulrich Jaeger, Elvira D'Ippolito,Dirk H. Busch
FRONTIERS IN IMMUNOLOGY (2024): 1268698-1268698
Transplantation and Cellular Therapyno. 2 (2023): S13-S13
Blood advancesno. 22 (2023): 6990-7005
引用0浏览0引用
0
0
Yaya Chu,Meijuna Tian,Uksha Saini, Jessica Ayala-Cuesta, Kayleigh Klose,Timothy P. Cripe,Dean A. Lee,Stanley Riddell,Kevin A. Cassady,Mitchell S. Cairo
引用0浏览0引用
0
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn