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My laboratory has been interested in the pathogenesis of murine coronavirus infections for several years. Now, we also study three respiratory human coronavirus infections: SARS (Severe Acute Respiratory Syndrome)-coronavirus, Middle East Respiratory syndrome (MERS)-coronavirus, SARS-CoV-2 (COVID-19), human coronavirus-OC43, and human coronavirus-NL63.
Mice infected with mouse hepatitis virus develop a demyelinating disease with many similarities to the human disease, multiple sclerosis. Research in my laboratory is aimed at determining the immunological and viral factors involved in the demyelinating process. Previously, we determined the CD4 and CD8 T cell epitopes recognized in the central nervous system (CNS) of infected mice. We showed that in mice infected chronically with the virus, cytotoxic T cell escape mutants arise. These mutations completely abrogate recognition by CD8 T cells and thereby facilitate persistence.
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论文共 25 篇作者统计合作学者相似作者
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Proceedings of the National Academy of Sciences of the United States of Americano. 31 (2023)
引用2浏览0WOS引用
2
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British Journal of Anaesthesiano. 2 (2022): e29-e32
Paul-Henri Lambert,Donna M. Ambrosino,Svein R. Andersen,Ralph S. Baric,Steven B. Black,Robert T. Chen, Cornelia L. Dekker,Arnaud M. Didierlaurent,Barney S. Graham, Samantha D. Martin,Deborah C. Molrine,Stanley Perlman,
Vaccineno. 31 (2020)
biorxiv(2020)
引用550浏览0引用
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Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2013)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2013)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2013)
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