Stanley B. Prusiner
教授
Institute for Neurodegenerative Diseases
School of Medicine, University of California, San Francisco;Department of Neurology and of Biochemistry & Biophysics, School of Medicine, University of California, San Francisco;Department of Virology, School of Public Health, University of California, Berkeley
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个人简介
Prusiner discovered an unprecedented class of pathogens that he named prions. Prions are proteins that acquire an alternative shape that becomes self-propagating. As prions accumulate, they cause neurodegenerative diseases in animals and humans. Prusiner’s discovery lead him to develop a novel disease paradigm: prions cause disorders such as Creutzfeldt-Jakob disease (CJD) in humans that manifest as (1) sporadic, (2) inherited and (3) infectious illnesses. When proposed, many scientists considered Prusiner’s concept of “infectious proteins” as well as his proposal that a single protein could possess multiple biologically active shapes or conformations to be heretical. Based on his seminal discovery that prions can assemble into amyloid fibrils, Prusiner proposed that the more common neurodegenerative diseases including Alzheimer’s and Parkinson’s diseases may be caused by prions. Remarkably, a wealth of evidence continues to accumulate arguing that prions cause not only these common degenerative diseases, but also ALS, the frontotemporal dementias (FTDs), chronic traumatic encephalopathy (CTE) and multiple system atrophy (MSA). Much of Prusiner’s current research focuses on developing therapeutics that reduce the levels of the specific prions responsible for Alzheimer’s, Parkinson’s, MSA, the FTDs, CTE and CJD.
Prusiner’s contributions to scientific research have been internationally recognized: He is a member of the National Academy of Sciences, the Institute of Medicine, the American Academy of Arts and Sciences and the American Philosophical Society, and a foreign member of the Royal Society, London. He is the recipient of numerous prizes, including the Potamkin Prize for Alzheimer’s Disease Research from the American Academy of Neurology (1991); the Richard Lounsbery Award for Extraordinary Scientific Research in Biology and Medicine from the National Academy of Sciences (1993); the Gairdner Foundation International Award (1993); the Albert Lasker Award for Basic Medical Research (1994); the Wolf Prize in Medicine from the State of Israel (1996); the Nobel Prize in Physiology or Medicine (1997); and the United States Presidential National Medal of Science (2009).
Prusiner’s contributions to scientific research have been internationally recognized: He is a member of the National Academy of Sciences, the Institute of Medicine, the American Academy of Arts and Sciences and the American Philosophical Society, and a foreign member of the Royal Society, London. He is the recipient of numerous prizes, including the Potamkin Prize for Alzheimer’s Disease Research from the American Academy of Neurology (1991); the Richard Lounsbery Award for Extraordinary Scientific Research in Biology and Medicine from the National Academy of Sciences (1993); the Gairdner Foundation International Award (1993); the Albert Lasker Award for Basic Medical Research (1994); the Wolf Prize in Medicine from the State of Israel (1996); the Nobel Prize in Physiology or Medicine (1997); and the United States Presidential National Medal of Science (2009).
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论文共 246 篇作者统计合作学者相似作者
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Ujjayini Ghosh,Eric Tse,Marie Shi, Hyunjun Yang, Feng Wang, Gregory E Merz,Stanley B Prusiner, Daniel R Southworth,Carlo Condello
bioRxiv : the preprint server for biology (2024)
Jacob I Ayers,Joanne Lee, Octovia Monteiro, Amanda L Woerman,Ann A Lazar,Carlo Condello, Nick A Paras,Stanley B Prusiner
PRIONno. SUPnan (2019): 4-4
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Tagan A. Griffin, Elisa M. Cleveland,Robert W. Newberry,George A. Carlson,Paul D. Schnier,Stanley B. Prusiner
PRIONno. SUPnan (2019): 8-9
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