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个人简介
Dr. Saladi’s research interests primarily focus on understanding the mechanism by which epigenetic reprogramming contributes to cellular plasticity in tumors. His research aims to define the mechanisms in which deregulated chromatin remodeling or altered chromatin landscape act as oncogenic drivers in cancer. Epigenetic reprogramming is a key oncogenic driver event in multiple cancers, however very little is known about the deregulated epigenetic programs in head and neck squamous cell carcinomas (HNSCC).
His research interests also include delineating the oncogenic role of hippo signaling pathway effector, YAP1 in squamous cell carcinomas. Hippo pathway was shown to bypass the MAPK oncogenic addiction in advanced stage of multiple cancers contributing to cancer progression. Dr. Saladi has unraveled the oncogenic role of Hippo pathway in HNSCC. He had identified WWC1 and GPRC5A (upstream inhibitors of oncogenic YAP1 activity) as repressed in HNSCC, thereby promoting tumorigenesis and conferring poor prognosis in a subset of HNSCC patients.
Collectively, Dr. Saladi integrates genomics, epigenetics, and signaling to dissect the mechanisms contributing to head and neck cancer maintenance and progression.
His research interests also include delineating the oncogenic role of hippo signaling pathway effector, YAP1 in squamous cell carcinomas. Hippo pathway was shown to bypass the MAPK oncogenic addiction in advanced stage of multiple cancers contributing to cancer progression. Dr. Saladi has unraveled the oncogenic role of Hippo pathway in HNSCC. He had identified WWC1 and GPRC5A (upstream inhibitors of oncogenic YAP1 activity) as repressed in HNSCC, thereby promoting tumorigenesis and conferring poor prognosis in a subset of HNSCC patients.
Collectively, Dr. Saladi integrates genomics, epigenetics, and signaling to dissect the mechanisms contributing to head and neck cancer maintenance and progression.
研究兴趣
论文共 46 篇作者统计合作学者相似作者
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Avinash Waghray, Isha Monga, Brian Lin,Viral Shah,Michal Slyper,Bruno Giotti,Jiajie Xu,Julia Waldman,Danielle Dionne,Lan T Nguyen, Wendy Lou,Peiwen Cai,
bioRxiv : the preprint server for biology (2023)
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Giulia Gobbi, Alessandra Grieco,Federica Torricelli,Elisabetta Sauta,Giacomo Santandrea,Eleonora Zanetti, Valentina Fantini,Francesca Reggiani,Silvia Strocchi,Massimiliano Paci,Manik Vohra,Srinivas Vinod Saladi,
Cell Death and Diseaseno. 11 (2023): 1-14
Cancer Researchno. 7_Supplement (2023): 6425-6425
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crossref(2023)
Karina J. Matissek,Maristela L. Onozato,Sheng Sun,Zongli Zheng,Andrew Schultz,Jesse Lee, Kristofer Patel,Piiha-Lotta Jerevall,Srinivas Vinod Saladi,Allison Macleay, Mehrad Tavallai,Tanja Badovinac-Crnjevic,
crossref(2023)
Cell reportsno. 11 (2022): 110970-110970
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