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Research in the Booker Lab focuses on elucidating the chemical mechanisms by which enzymes containing iron-sulfur clusters catalyze chemical reactions. Most ongoing projects deal with members of the Radical S-adenosylmethionine Superfamily, a diverse group of enzymes that employ radical chemistry to catalyze transformations involved in post-transcriptional and post-translational modifications, cofactor biosynthesis, secondary metabolite biosynthesis, and enzyme activation. Radical SAM enzymes share a [4Fe-4S] cluster cofactor that is used to reductively cleave S-adenosylmethionine and form the 5’-deoxyadenosyl radical, a potent oxidant typically used to abstract a hydrogen atom and initiate radical chemistry on the substrate. These remarkable enzymes utilize this initial shared step to catalyze a wide array of transformations including methylations, sulfur insertions, decarboxylations, and complex rearrangements. Using a combination of biochemical, analytical, structural, and spectroscopic techniques, the Booker Lab works to characterize these complex and intriguing reaction mechanisms to provide insight for applications to human health and disease and gain a greater understanding of how Nature has worked to solve difficult chemical problems.
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论文共 182 篇作者统计合作学者相似作者
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Peter Tsvetkov, Nolan Bick, Margaret Dreishpoon,Douglas Warui,Naama Kanarek,Sandro Santagata,Squire Booker,Todd Golub,Peter Tsvetkov
Journal of Biological Chemistryno. 3 (2024)
Journal of Biological Chemistryno. 3 (2024)
ACS BIO & MED CHEM AUno. 1 (2024): 1-3
JOURNAL OF BIOLOGICAL CHEMISTRYno. 3 (2023): S302-S302
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Margaret B. Dreishpoon, Nolan R. Bick,Boryana Petrova,Douglas M. Warui, Alison Cameron,Squire J. Booker,Naama Kanarek,Todd R. Golub,Peter Tsvetkov
ACS CENTRAL SCIENCEno. 5 (2023): 905-914
Squire J Booker, Cody T Lloyd
ACS bio & med chem Auno. 6 (2022): 538-547
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