His research interests include preconception counselling, high-risk pregnancy, maternal physiology, gender-sensitive cardiovascular disease and health and health education. Prevention of cardiovascular disease is the central theme in his research.

At Radboud university medical center, Prof. Spaanderman will dedicate himself to building a care and research expertise network within the scientific theme Vascular damage. That network will focus on women with an increased risk of cardiovascular dysfunction with the aim of improving and maintaining health before, during and after pregnancy.