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Our research aim is to understand the cellular and tissue-specific roles of factors involved in protein quality control pathways, with a particular emphasis on the pathways that detect and specifically destroy these dangerous molecules. An understanding of these pathways allows us to define the mechanisms that protect the organismal proteome in health and disease, and eventually devise methods to harness cellular quality control to modify the proteome in the laboratory and the clinic. As a first step towards this goal, we are focused on discovering and studying proteostasis pathways in yeast, mammalian cells and zebrafish, allowing us to synergistically capitalize on the investigative strengths that each has to offer. We take advantage of the laboratory’s unique set of skills in genetics, biochemistry, functional genomics, cell and molecular biology to extend these lines of inquiry and to train the next generation of scientific leaders.
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论文共 25 篇作者统计合作学者相似作者
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SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2024): 107-120
Rachel Kandel,Jasmine Jung, Della Syau,Tiffany Kuo,Livia Songster, Casey Horn, Claire Chapman, Analine Aguayo,Sascha Duttke, Christopher Benner,Sonya E Neal
MOLECULAR BIOLOGY OF THE CELLno. 2 (2023): 678-678
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Journal of Biological Chemistryno. 3 (2023): 104080-S581
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Biophysical Journalno. 3 (2022): 442a-442a
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