基本信息
浏览量:164
职业迁徙
个人简介
Our laboratory is interested in understanding the role of highly spatio-temporal localized Ca2+ signals, namely Ca2+ sparks, in normal cell function and diseases (e.g., heart failure, arrhythmias and other disease). We use state of the art techniques such as patch-clamp and laser scanning confocal microscopy in combination with genetic mouse models to investigate the cellular mechanisms of Ca2+ regulation and dysregulation. Specifically, we are studying 1) the structure-function relationship between t-tubule system and Ca2+ handling in normal and diseased hearts. In this project, we are testing our hypothesis that t-tubule remodeling plays critical role in Ca2+ release instability and therefore Ca2+-dependent arrhythmogenesis in cardiomyopathies; 2) molecular mechanisms of t-tubule remodeling in heart disease. We are actively searching for the molecules that control and regulate t-tubule organization in cardiomyocytes; 3) Local Ca2+ signaling and sinoatrial node automaticity. In the third project, we are testing our hypothesis that Ca2+ sparks are highly locally controlled in sinoatrial nodal cells and that dys-regulation of local Ca2+ signaling in SAN cells contributes to pacemaker dysfunction. Our research projects are funded by National Heart, Lung and Blood Institute, American Heart Association.
研究兴趣
论文共 188 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Chen Xu, Ge Zhang,Xinjian Wang, Xiaozhi Huang,Jiayin Zhang, Shuxian Han,Jinxi Wang,Duane D Hall,Ruoqing Xu,Feng He,Xing Chang,Fudi Wang,
Circulation (2024)
CARDIOVASCULAR RESEARCH (2024)
Antentor Hinton,Prasanna Katti, Margaret Mungai,Duane D. Hall,Olha Koval,Jianqiang Shao,Zer Vue, Edgar Garza Lopez, Rahmati Rostami,Kit Neikirk,Jessica Ponce,Jennifer Streeter,
Journal of Cellular Physiologyno. 4 (2024)
Heart rhythm (2024)
Antentor Hinton,Prasanna Katti, Margaret Mungai,Duane D. Hall,Olha Koval,Jianqiang Shao,Zer Vue, Edgar Garza Lopez, Rahmati Rostami,Kit Neikirk, Jessica Ponce,Jennifer Streeter,
JOURNAL OF CELLULAR PHYSIOLOGY (2024)
Cardiovascular research (2024)
MOLECULAR THERAPY NUCLEIC ACIDS (2023): 102081-102081
CIRCULATION RESEARCHno. Suppl_1 (2023)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn