Professor David L Smith and his team use multiple quantitative methods in an expansive research program that addresses questions in basic science, computational epidemiology, disease ecology, mathematical modeling, and policy analytics for global health. A key goal is to quantify and propagate uncertainty to improve scientific inference and provide robust policy advice. Smith has published on several diseases including malaria, influenza, rabies, dengue, yellow fever, cholera and nosocomial bacterial pathogens such as Staphylococcus aureus and enterococci. His research has covered themes relating to mosquito ecology, mosquito-borne pathogen transmission, human and mosquito mobility, the spatial dynamics of infectious diseases, evolution of resistance, disease control, and malaria elimination and eradication. Smith is a member of the Malaria Atlas Project, a contributor to the Global and Local Burden of Diseases Studies, and PI of the Malaria Modeling Consortium Secretariat.