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个人简介
The research in my laboratory is focused on understanding the functions and mechanisms of enzymes involved in genome replication and transcription. We use among various methods transient state kinetics (rapid chemical quench-flow and stopped-flow) and fluorescence including time-resolved FRET to study enzymatic reaction dynamics. We combine enzymological studies with structure-function and single molecule studies in collaboration to achieve a detailed understanding of the workings of an enzyme. We use powerful computational methods to model the experimental data to understand and decipher the detailed pathways of enzymatic reactions. We are currently investigating a) replicative enzymes: helicases and DNA polymerase b) transcriptional enzymes: DNA-dependent RNA polymerase. and c) viral replicases: HCV RNA helicase and RNA polymerase.
研究兴趣
论文共 387 篇作者统计合作学者相似作者
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Ryan Woltz,Brandon Schweibenz,Susan E Tsutakawa,Chen Zhao,LiChung Ma, Ben Shurina,Gregory L Hura, Rachael John,Sergey Vorobiev, Gvt Swapna,Mihai Solotchi,John A Tainer,
bioRxiv : the preprint server for biology (2024)
NUCLEIC ACIDS RESEARCHno. 1 (2024): 355-369
Ryan Woltz,Brandon Schweibenz,Susan E. Tsutakawa,Chen Zhao,Li-Chung Ma,Ben Shurina,Greg L Hura, Rachael John,Sergey Vorobiev, Swapna Gurla,Mihai Solotchi,John A. Tainer,
bioRxiv (Cold Spring Harbor Laboratory) (2024)
medRxiv (Cold Spring Harbor Laboratory) (2023)
Journal of the American Chemical Societyno. 45 (2023): 24522-24534
S. Lu,F.G.M. De Braud, Y. Fan, X. Hu, Y. Ohe,Y. Yu,M-J. Ahn, P. Cassier,J.J. Lin, L. Paz-Ares, C. Xue, W. Bordogna,
Annals of Oncology (2023): S468-S469
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The Journal of biological chemistryno. 1 (2023): 102797-102797
Nucleic acids researchno. 15 (2023): 8102-8114
Natureno. 7984 (2023): 872-879
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