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个人简介
As a developmental pediatrician and neonatologist I have been interested in developmental brain injury that leads to functional deficits in children suffering from such conditions. From our preclinical work, that includes the use of different models of developmental brain injury and advanced magnetic resonance neuroimaging with a strong translational aspect to neuropathology seen in preterm and growth restricted newborns, we have been able to delineate damage but more importantly in the scope of the current proposal, to test for neuroprotective strategies for this vulnerable population. This especially includes the use of Lactoferrin (Lf) during gestation and lactation. The anti-inflammatory, anti-oxidant and anti-apoptotic properties of Lf have the potential to reduce developmental brain injury, including postnatal hypoxic-ischemic, inflammatory and intra-uterine fetal injury, the three being major mechanisms of injury in the developing brain. From these preclinical data, we believe that Lf given as a nutrient supplement has a great potential to reduce brain damage in preterm and growth restricted newborns in addition to its protective effect in neonatal sepsis and necrotizing enterocolitis.
More recently we have implemented research on cerebral palsy and sensori-motor intensive therapy in preclinical models to investigate brain changes and plasticity as response to therapy. Also using a mice model of San Filippo disease (neurodegenerative disease in children) we will characterize brain neuropathology including in vivo metabolic and structural changes using magnetic resonance and effects of treatment with heparan sulphate to alleviate brain damage.
We have the ability to perform this clinical research especially in regard to neuroimaging of this population and neurodevelopmental assessment.
研究兴趣
论文共 134 篇作者统计合作学者相似作者
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Rodrigo Araneda,Daniela Ebner-Karestinos,Julie Paradis,Anne Klocker,Geoffroy Saussez,Josselin Demas,Rodolphe Bailly,Sandra Bouvier, Astrid Carton de Tournai,Enimie Herman, Aghiles Souki,Gregoire Le Gal,
International Journal of Molecular Sciencesno. 21 (2023): 15583-15583
Rodrigo Araneda,Daniela Ebner‐Karestinos,Julie Paradis,Anne Klöcker,Geoffroy Saussez,Josselin Démas,Rodolphe Bailly,Sandra Bouvier, Astrid Carton de Tournai,Herman Enimie, A. Souki,Grégoire Le Gal,
JAMA Pediatrics (2023)
Rodrigo Araneda,Daniela Ebner‐Karestinos,Julie Paradis,Rodolphe Bailly,Sandra Bouvier,Anne Klöcker,Geoffroy Saussez,Josselin Démas,Stéphane Sizonenko, Christopher L. Newman,Mickaël Dinomais, Grégoire Legal,
Kinésithérapie, la Revueno. 255 (2023): 62-62
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