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We demonstrated a role for autophagy in mobilization and degradation of intracellular lipid stores by a process we termed lipophagy, thus mapping autophagy to metabolic regulation. We have recently shown that lipophagy in hypothalamic neurons generates neuron-intrinsic free fatty acids that drive neuronal feeding mechanisms. The primary focus of the lab is to examine the organ-specific roles of autophagy in the regulation of lipid metabolism and energy homeostasis using biochemical, immunohistochemical, and image-based approaches in vitro and in conditional knockout mouse models. More specifically, our interests lie in understanding how autophagy in the CNS and peripheral tissues controls energy, glucose, and lipid metabolism in a time-, diet-, and age-dependent manner.
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论文共 78 篇作者统计合作学者相似作者
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Ashwaq H. Yehya, Nathan Pham, Linsey Stiles,Nuria Martinez-Lopez, Hoa A. Lam,Rajat Singh,Nigel T. Maidment,Elizabeth J. Videlock
Gastroenterologyno. 5 (2024): S-488
Nuria Martinez-Lopez, Pamela Mattar,Miriam Toledo, Henrietta Bains,Manu Kalyani,Marie Louise Aoun,Mridul Sharma, Laura Beth J. McIntire,Leslie Gunther-Cummins,Frank P. Macaluso,Jennifer T. Aguilan,Simone Sidoli,
Debajyoti Das,Mridul Sharma,Deepanshi Gahlot, Jennifer T. Aguilan, Simone Sidoli,Mathieu Bourdenx, Lipi Thakural,Nuria Martinez-Lopez,Rajat Singh
HEPATOLOGY (2023): S1981-S1981
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Nuria Martinez-Lopez,Pamela Mattar, Miriam Toledo, Henrietta Bains,Mridul Sharma,Laura Beth J. McIntire,Leslie Gunther-Cummins, Frank P. Macaluso, Jennifer T. Aguilan, Simone Sidoli,Mathieu Bourdenx,Rajat Singh
HEPATOLOGY (2023): S1984-S1985
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Cell metabolismno. 7 (2023): 1114-1131
Henrietta Bains, Debajyoti Das,Nuria Martinez-Lopez, Jennifer T. Aguilan, Simone Sidoli,Mathieu Bourdenx,Laura Beth J. McIntire,Rajat Singh
HEPATOLOGY (2023): S1983-S1983
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Pamela Mattar, Andressa Reginato, Christian Lavados,Nuria Martinez-Lopez,Mridul Sharma, Gary Schwartz, Prashant Rajbhandari,Rajat Singh
HEPATOLOGY (2023): S1148-S1148
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Elodie Picarda,Phillip M Galbo, Haihong Zong, Meenu Rohini Rajan,Ville Wallenius,Deyou Zheng,Emma Börgeson,Rajat Singh,Jeffrey Pessin,Xingxing Zang
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