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I have a longstanding interest in leukaemia research started with my PhD and my principal aim is to understand how physiological ageing and leukemogenesis interact: Acute Myeloid Leukaemia (AML) incidence increases dramatically with age, and is far harder to treat in the elderly. A better understanding of how AML progression is affected by ageing is therefore urgently needed.
My hypothesis is based on preliminary data obtained working on normal ageing and AML models, showing that key molecular changes that occur in bone marrow stromal cells during AML progression parallel those that are seen during normal ageing. My final goal is to determine how the aged microenvironment influences AML progression, identifying new therapeutic candidates that are likely to be useful for treating AML in the elderly.
My hypothesis is based on preliminary data obtained working on normal ageing and AML models, showing that key molecular changes that occur in bone marrow stromal cells during AML progression parallel those that are seen during normal ageing. My final goal is to determine how the aged microenvironment influences AML progression, identifying new therapeutic candidates that are likely to be useful for treating AML in the elderly.
研究兴趣
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HemaSphereno. S3 (2023): e8112156-e8112156
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Nature Cell Biologyno. 6 (2023): 812-822
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Experimental Hematology (2022): S52-S52
Cancer cellno. 5 (2020): 690-704.e8
C Nerlov, C Di Genua,S Valletta,M Buono,B Stoilova,C Sweeney,A Rodriguez-Meira, A Grover,Y Meng, R Beveridge, Z Aboukhalil,D Karamitros,
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