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Simon Melov, PhD, who heads the Institute’s Genomic Core, explores the role of the energy-making units inside cells, the mitochondria, which produce a chemical fuel that powers the cell’s work but which also release damaging “free radicals’’ that are linked to disease. The Melov lab studies proteins that help the mitochondria detoxify free radicals and tracks the decline of function in mitochondria that comes with age. Other research interests include the age-related bone disorder osteoporosis, age-related heart disease, the role of methylation in the aging human genome, and developing molecular techniques to better understand single cell changes with age. In a landmark study, Melov and collaborators showed that the more vigorous pattern of gene expression found in young adults could be partially restored in older adults who followed an strength training exercise program for 6 months. The Melov lab looks for broader genetic fingerprints of aging by surveying the patterns of gene activity in various animals, including human beings, mice, and the nematode worm C. elegans.
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论文共 195 篇作者统计合作学者相似作者
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Charles A. Schurman,Serra Kaya,Neha Dole, Nadja M. Maldonado Luna, Natalia Castillo, Ryan Potter,Jacob P. Rose,Joanna Bons,Christina D. King,Jordan B. Burton,Birgit Schilling,Simon Melov,
Bone Researchno. 1 (2024): 1-17
Sophia A. Mahoney,Ravinandan Venkatasubramanian, Mary A. Darrah,Katelyn R. Ludwig,Nicholas S. Vandongen,Nathan T. Greenberg, Abigail G. Longtine,David A. Hutton,Vienna E. Brunt,Judith Campisi,Simon Melov,Douglas R. Seals,
Stefanie Deinhardt-Emmer, Sharvari Deshpande,Koji Kitazawa,Allison B. Herman,Joanna Bons,Jacob P. Rose, Prasanna Ashok Kumar,Carlos Anerillas,Francesco Neri,Serban Ciotlos,Kevin Perez,Nilay Koese-Vogel,
PHYSIOLOGYno. S1 (2023)
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Chase M Carver, Paul T Gomez, Sonia L Rodriguez,Jennifer M Kachergus, Yi Liu, Ji Shi, Tommy Tran, Liguo Wang,Simon Melov,E Aubrey Thompson,Marissa J Schafer
Research square (2023)
Charles A. Schurman,Serra Kaya,Neha S Dole, Natalí Jazmin De la Cerna Luna, Natalia Alejandra Castillo,Ryan Potter,Jacob Rose,Joanna Bons,Christina D. King,Jordan B. Burton,Birgit Schilling,Simon Melov,
Research Square (Research Square) (2023)
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Lauren Wimer,Elena A. Goncharova, Sofiya Galkina,Edna Nyangau,Mahalakshmi Shankaran, A. Davis,Leandro Prado, Marina Cecilia Muñoz, Sharon Epstein, Cavan Patterson, Nicholas Shaum, M. K. Hellerstein,
Aging Cellno. 8 (2023)
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Marco Demaria, Monique N. O'Leary,Jianhui Chang,Lijian Shao,Su Liu,Fatouma Alimirah,Kristin Koenig, Catherine Le,Natalia Mitin,Allison M. Deal,Shani Alston,Emmeline C. Academia,
crossref(2023)
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