基本信息
浏览量:51
职业迁徙
个人简介
Siegfried Hekimi was born in Zürich and obtained his undergraduate degree in Biology at the University of Geneva. He did not immediately pursue graduate studies but instead engaged in a full-time career as a cyclist, first as a member of the amateur Swiss National Team and then as a professional in various teams in Switzerland and Italy. He was selected for the World Championships four times and participated in such well known races as the Tour de France and the Giro d'Italia. After this adventure he completed a PhD in Neurobiology in 1988 with Professor Michael O'Shea, again at the University of Geneva. His thesis focused on the biosynthesis of neuropeptides, which was poorly understood at the time.
It was to tackle this problem that he first developed an interest in using invertebrate models to study evolutionarily conserved processes. This approach led him to study the cardiac bodies of locusts, a pair of endocrine glands almost completely dedicated to the production of the peptidic adipokinetic hormones. He then moved to the famed Laboratory of Molecular Biology (LMB) of the Medical Research Council in Cambridge, UK, to collaborate with Dr J.G. White as a post-doctoral fellow of the Swiss National Science Fund. It is at the LMB that Sydney Brenner developed the nematode Caenorhabditis elegans as one of the premier research tools in genetics, and where Hekimi developed his interest for using 'the worm' for translational studies in the biology of aging. It is also in Cambridge that he identified the first mutants that helped to demonstrate that aging could be manipulated genetically and that inducing mild mitochondrial dysfunction could in fact slow down the aging process of animals. After three years in Cambridge, Hekimi joined the Department of Biology at McGill University.
It was to tackle this problem that he first developed an interest in using invertebrate models to study evolutionarily conserved processes. This approach led him to study the cardiac bodies of locusts, a pair of endocrine glands almost completely dedicated to the production of the peptidic adipokinetic hormones. He then moved to the famed Laboratory of Molecular Biology (LMB) of the Medical Research Council in Cambridge, UK, to collaborate with Dr J.G. White as a post-doctoral fellow of the Swiss National Science Fund. It is at the LMB that Sydney Brenner developed the nematode Caenorhabditis elegans as one of the premier research tools in genetics, and where Hekimi developed his interest for using 'the worm' for translational studies in the biology of aging. It is also in Cambridge that he identified the first mutants that helped to demonstrate that aging could be manipulated genetically and that inducing mild mitochondrial dysfunction could in fact slow down the aging process of animals. After three years in Cambridge, Hekimi joined the Department of Biology at McGill University.
研究兴趣
论文共 170 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Francis Robert,John R. Mills, Aouod Agenor,Dantong Wang, Sergio DiMarco,Regina Cencic,Michel L. Tremblay,Imed Eddine Gallouzi,Siegfried Hekimi,Simon S. Wing,Jerry Pelletier
crossref(2023)
crossref(2023)
crossref(2023)
Francis Robert,John R. Mills, Aouod Agenor,Dantong Wang, Sergio DiMarco,Regina Cencic,Michel L. Tremblay,Imed Eddine Gallouzi,Siegfried Hekimi,Simon S. Wing,Jerry Pelletier
crossref(2023)
Francis Robert,John R. Mills, Aouod Agenor,Dantong Wang, Sergio DiMarco,Regina Cencic,Michel L. Tremblay,Imed Eddine Gallouzi,Siegfried Hekimi,Simon S. Wing,Jerry Pelletier
crossref(2023)
crossref(2023)
Adriana P Rebelo,Pedro J Tomaselli,Jessica Medina,Ying Wang,Maike Dohrn,Eva Nyvltova, Matt Denzi, Mark Garrett,Sean Smith,Alan Pestronk, ChengCheng Li,Ariel Ruiz,
引用3浏览0WOS引用
3
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn