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The Sheng laboratory investigates the underlying molecular mechanisms of prostate tumor progression, metastasis and drug sensitivity, using a full spectrum of cancer biology methodologies. Specifically, the lab studies maspin, a novel tumor suppressive serine protease inhibitor. Dr. Sheng and colleagues have shown that epithelial-specific maspin inhibits tumor invasion and metastasis, and maspin sensitizes tumor cells to drug induced apoptosis. Interestingly, maspin does not inhibit any active serine proteases. Recently, the Sheng lab identified histone deacetylase 1 (HDAC1) and pro-urokinase type plasminogen activator (pro-uPA) as the molecular targets of maspin. These breakthroughs are of potentially high impact and clinical significance. The focus of a current project in the Sheng laboratory is to study how maspin blocks pro-uPA-mediated stromal remodeling in bone microenvironment, a preferred site for prostate tumor metastasis. Another project investigates the hypothesis that by inhibiting HDACA1, maspin sensitizes tumor cells to drug-induced apoptosis while preventing adverse epithelial dedifferentiation.
研究兴趣
论文共 73 篇作者统计合作学者相似作者
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M. Margarida Bernardo,Alexander Kaplun,Sijana H. Dzinic,Xiaohua Li,Jonathan Irish, Adelina Mujagic, Benjamin Jakupovic,Jessica B. Back,Eric Van Buren,Xiang Han,Ivory Dean,Yong Q. Chen,
crossref(2023)
crossref(2023)
M. Margarida Bernardo,Alexander Kaplun,Sijana H. Dzinic,Xiaohua Li,Jonathan Irish, Adelina Mujagic, Benjamin Jakupovic,Jessica B. Back,Eric Van Buren,Xiang Han,Ivory Dean,Yong Q. Chen,
crossref(2023)
Cancer and Metastasis Reviewsno. 4 (2022): 965-974
Sijana H Dzinic,Zaid Mahdi,M Margarida Bernardo,Semir Vranic,Haya Beydoun, Nadine Nahra, Amra Alijagic,Deanna Harajli, Aaron Pang,Dan M Saliganan, Abid M Rahman,Faruk Skenderi,
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