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The goal of research group is to elucidate chromatin regulatory mechanisms engaged in development and function of the brain. Chromatin deregulation has emerged as a major cause of neurodevelopmental disorders such as intellectual disabilities, autism spectrum disorders, and schizophrenia. Post-translational modifications of histones have been recognized as a "language" describing a variety of nuclear events. Numerous mutations associated with neurodevelopmental fall into such histone modification regulators. Accurate interpretation of the histone modification network, therefore, appears to be essential for proper brain development and function. However, little is known about what chromatin regulators do in the brain and how these mutations lead to neurodevelopmental disorders. Our group aims to reveal molecular underpinnings of histone regulation in the brain, thereby understanding of the roles of chromatin in normal and pathological brains.
The goal of research group is to elucidate chromatin regulatory mechanisms engaged in development and function of the brain. Chromatin deregulation has emerged as a major cause of neurodevelopmental disorders such as intellectual disabilities, autism spectrum disorders, and schizophrenia. Post-translational modifications of histones have been recognized as a "language" describing a variety of nuclear events. Numerous mutations associated with neurodevelopmental fall into such histone modification regulators. Accurate interpretation of the histone modification network, therefore, appears to be essential for proper brain development and function. However, little is known about what chromatin regulators do in the brain and how these mutations lead to neurodevelopmental disorders. Our group aims to reveal molecular underpinnings of histone regulation in the brain, thereby understanding of the roles of chromatin in normal and pathological brains.
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论文共 63 篇作者统计合作学者相似作者
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bioRxiv : the preprint server for biology (2024)
Le Tran Phuc Khoa,Wentao Yang,Mengrou Shan,Li Zhang,Fengbiao Mao,Bo Zhou,Qiang Li, Rebecca Malcore, Clair Harris, Lili Zhao,Rajesh C. Rao,Shigeki Iwase,
Le Tran Phuc Khoa,Wentao Yang,Mengrou Shan,Li Zhang,Fengbiao Mao,Bo Zhou,Qiang Li, Rebecca Malcore, Clair Harris, Lili Zhao,Rajesh C. Rao,Shigeki Iwase,
Genetics in Medicine Openno. 1 (2023): 100381-100381
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Pilar Rivero-Rios, Takao Tsukahara, Tunahan Uygun,Alex Chen, Garrett Chavis,Sai Giridharan,Shigeki Iwase,Michael Sutton,Lois Weisman
IBRO Neuroscience Reports (2023): S333-S333
bioRxiv : the preprint server for biology (2023)
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Robert S Porter, Masayoshi Nagai,Sojin An, Maria C Gavilan,Yumie Murata-Nakamura,Katherine M Bonefas,Bo Zhou, Olivier Dionne, Jeru Manoj Manuel, Joannie St-Germain, Liam Browning,Benoit Laurent,
bioRxiv : the preprint server for biology (2023)
Pilar Rivero-Ríos, Takao Tsukahara, Tunahan Uygun, Alex Chen,Garrett D. Chavis,Sai Srinivas Panapakkam Giridharan,Shigeki Iwase,Michael A. Sutton,Lois S. Weisman
biorxiv(2023)
Biochemical Society transactionsno. 2 (2023): 703-713
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