基本信息
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职业迁徙
个人简介
We develop computer models for biomolecular structure and function with focus on RNA molecules. Biological molecules are large organic molecules composed of hundreds or thousands of atoms bound together by covalent bonds into a chain-like structure. One of the best known challenges in biology is to understand how biomolecules fold properly into compact structures to perform biological functions and how they misfold to cause disease. We develop computational methods to study RNA folding, predict RNA 3D structures, and model RNA-small molecule and RNA-metal ion interactions, RNA in vivo folding kinetics, and cellular functions at the level of gene expression and regulation. Furthermore, through collaborations with experimental labs, we design RNA-based therapeutic strategies involving aptamer binding and CRISPR-Cas9 gene editing.
研究兴趣
论文共 101 篇作者统计合作学者相似作者
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Biophysical Journal (2024)
bioRxiv : the preprint server for biology (2024): 103069-103069
Artificial Intelligence Chemistryno. 1 (2024): 100053
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICSno. 12 (2023): 1779-1789
John S. Samuelian,Thomas J. Gremminger,Zhenwei Song,Raghav R. Poudyal,Jun Li,Yuanzhe Zhou, Seth A. Staller, Johan A. Carballo, Manami Roychowdhury-Saha,Shi-Jie Chen,Donald H. Burke,Xiao Heng,
RNA Nanotechnology and Therapeuticspp.447-461, (2022)
QRB Discovery (2022): 1-22
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D-Core
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