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Due to their expansive utility, stem cell-based therapies hold the potential to redefine therapeutic approaches and provide cures for many terminal diseases. In the Hingtgen lab, we seek to harness the potential of stem cells to develop new and better methods for treating terminal cancers, including brain, breast, lung, and others. We use an integrative approach that begins with creating specially designed targeted therapeutic proteins. We then “arm” different stem cell types with the anti-cancer molecules, and investigate the ability of stem cell-based therapies to improve both drug delivery and cancer cell killing using various small animal models of human cancer. Central to our research is the extensive integration of non-invasive imaging. We use multiple imaging modalities to provide real-time dynamic feedback on stem cell and tumor cell volumes and distribution, pharmacokinetics of drug delivery, and the overall effectiveness of our therapeutic approaches. By bringing together the tools and techniques of molecular biology, viral vectors, targeted therapeutics, stem cell biology, and molecular imaging with highly translatable animal models, we hope to ultimately bring successful cell-based treatments for multiple tumor types into the clinics.
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论文共 133 篇作者统计合作学者相似作者
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Xing Cheng,Jing An,Jitong Lou,Qisheng Gu,Weimin Ding, Gaith Nabil Droby, Yilin Wang, Chenghao Wang,Yanzhe Gao, Jay Ramanlal Anand,Abigail Shelton,Andrew Benson Satterlee,
Nature Communicationsno. 1 (2024): 1-20
Dina Abdelnabi,Sarah Lastakchi,Colin Watts, Hannah Atkins,Shawn Hingtgen,Alain Valdivia,Christopher McConville
Alain Valdivia, Adebimpe Adefolaju,Morrent Thang, Luz Andrea Cuaboy,Catherine John,Breanna Mann,Andrew Satterlee,Victoria L Bae-Jump,Shawn Hingtgen
biorxiv(2024)
Thomas M. Kierski,Juan D. Rojas,Morrent Thang,Shawn D. Hingtgen,Phillip G. Durham,Paul A. Dayton, Tomek J. Czernuszewicz,Ryan C. Gessner
Cancer Researchno. 6_Supplement (2024): 4159-4159
Neuro-oncology advancesno. 1 (2023): vdad047-vdad047
Neuro-oncologyno. Supplement_5 (2023): v31-v32
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Esther Arwert,Shawn Hingtgen, Jose-Luiz Figueiredo, Henry Bergquist,Umar Mahmood,Ralph Weissleder,Khalid Shah
crossref(2023)
Neuro-oncologyno. Supplement_5 (2023): v308-v308
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MOLECULAR THERAPYno. 4 (2023): 477-477
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Neuro-oncologyno. Supplement_5 (2023): v226-v226
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