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Research in my lab aims to address the fundamental question of “how do cells work together to collectively build complex tissues?”. In particular, how are groups of cells able to interpret a signal, accurately communicate this information to neighbouring cells and precisely coordinate their communal cell behaviour, morphology and identity to drive functional organ formation?
This question is core to understanding how all tissues form during embryonic development via the process of “morphogenesis” - whereby un-patterned cell populations elegantly reorganise into distinct organs and tissues. Moreover, such communal coordination of cell behaviour also critically underpins the repair or regeneration of tissues following damage, and these processes are frequently subverted in disease. As such, the ultimate aim of our work is to exploit knowledge of these mechanisms to realise novel therapeutic strategies tackling pathological tissue formation and/or repair in disease states as diverse as myocardial infarction, chronic wounds and cancer.
This question is core to understanding how all tissues form during embryonic development via the process of “morphogenesis” - whereby un-patterned cell populations elegantly reorganise into distinct organs and tissues. Moreover, such communal coordination of cell behaviour also critically underpins the repair or regeneration of tissues following damage, and these processes are frequently subverted in disease. As such, the ultimate aim of our work is to exploit knowledge of these mechanisms to realise novel therapeutic strategies tackling pathological tissue formation and/or repair in disease states as diverse as myocardial infarction, chronic wounds and cancer.
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论文共 27 篇作者统计合作学者相似作者
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bioRxiv : the preprint server for biology (2023)
GENES & DEVELOPMENTno. 19-20 (2022): 1096-1096
Bahti Zakirov,Georgios Charalambous, Raphael Thuret,Irene M. Aspalter,Kelvin Van-Vuuren,Thomas Mead, Kyle Harrington,Erzsebet Ravasz Regan,Shane Paul Herbert,Katie Bentley
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCESno. 1821 (2021): 20190753-20190753
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