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The Samarajiwa lab studies gene and epigenome regulatory processes that contribute to normal physiology and disease pathology. This includes the regulation of host defence responses (antiviral, inflammatory, anti-tumour responses), ageing, immune & inflammatory diseases and carcinogenesis.
Perturbation of the cellular information flow due to mutations, genetic aberrations, ploidy, metabolic reprogramming and cellular pathway and network deregulation, results in complex phenotypes that promote disease states. The Samarajiwa lab integratively studies gene (transcriptome and translatome), epigenome and chromatin architecture regulation affecting these processes and phenotypes at the systems level.
Perturbation of the cellular information flow due to mutations, genetic aberrations, ploidy, metabolic reprogramming and cellular pathway and network deregulation, results in complex phenotypes that promote disease states. The Samarajiwa lab integratively studies gene (transcriptome and translatome), epigenome and chromatin architecture regulation affecting these processes and phenotypes at the systems level.
研究兴趣
论文共 54 篇作者统计合作学者相似作者
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Joana M. Xavier,Ramiro Magno,Roslin Russell,Bernardo P. de Almeida, Ana Jacinta-Fernandes, André Duarte,Mark Dunning,Shamith Samarajiwa, Martin O’Reilly, António M. Maia, Cátia L. Rocha,Nordiana Rosli,
medrxiv(2023)
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CANCER RESEARCHno. 16 (2023): PR002-PR002
J. M. Xavier, R. Magno, R. Russell,B. P. de Almeida, A. Jacinta-Fernandes, A. Duarte,M. Dunning,S. Samarajiwa, M. O' Reilly, C. L. Rocha, N. Rosli,B. A. J. Ponder,
medRxiv (2022)
Science Advancesno. 39 (2022): eabn9828-eabn9828
Chun Gong,Joanna A Krupka,Jie Gao,Nicholas F Grigoropoulos,George Giotopoulos,Ryan Asby,Michael Screen,Zelvera Usheva,Francesco Cucco,Sharon Barrans,Daniel Painter, Nurmahirah Binte Mohammed Zaini,
Rossi S., Newsham I., Pita S.,Park G., Lach R., Babbage A.,Smith C., Brennan K., Mitchell T., Warren A.,Gevaert O.,Leppert J.,
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Jie Gao, Eirini Sidiropoulou,Ieuan Walker,Joanna Alicja Krupka, Karol Mizielinski,Zelvera Usheva,Shamith A Samarajiwa,Daniel J Hodson
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