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Seychelle M. Vos investigates how genome organization and gene expression are physically coupled across molecular scales.
We study the interplay of gene expression and genome organization. Our work focuses on understanding how large molecular machineries involved in genome organization and gene transcription regulate each others’ function to ultimately determine cell fate and identity. We employ a broad range of approaches including single-particle cryo-electron microscopy (cryo-EM), X-ray crystallography, biochemistry, and genetics to mechanistically understand how these molecular assemblies regulate each other across molecular scales.
We study the interplay of gene expression and genome organization. Our work focuses on understanding how large molecular machineries involved in genome organization and gene transcription regulate each others’ function to ultimately determine cell fate and identity. We employ a broad range of approaches including single-particle cryo-electron microscopy (cryo-EM), X-ray crystallography, biochemistry, and genetics to mechanistically understand how these molecular assemblies regulate each other across molecular scales.
研究兴趣
论文共 39 篇作者统计合作学者相似作者
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Molecular Cell (2024)
Jiawei Zhao,Liam D. Cato, Uma P. Arora,Erik L. Bao, Samuel C. Bryant,Nicholas Williams, Yuemen Jia, Seth R. Goldman,Jyoti Nangalia,Michael A. Erb,Seychelle M. Vos,Scott A. Armstrong,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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bioRxiv : the preprint server for biology (2023)
Nature Communicationsno. 1 (2023): 1-11
Dimitrios Papadopoulos, Stefanie Anh Ha,Daniel Fleischhauer, Leonie Uhl, Katharina Schneider,Ivan Mikičić, Timothy J. Russell, Andrew S. Brem, Omkar Rajendra Valanju,Peter Gallant, Christina Sakarikou,Hans Michael Maric,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Molecular Cellno. 17 (2022): 3126-3134.e7
Yilai Li,Quanfu Fan,John Cohn, Veronique Demers, Ja Young Lee,Lucy Yip,Michael A. Cianfrocco,Seychelle M. Vos
biorxiv(2022)
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