基本信息
浏览量:188
职业迁徙
个人简介
Sevilla D Detera-Wadleigh’s (MS, PhD Biochemistry) research has focused on the genetics of mood disorders. To identify potential susceptibility regions for bipolar disorder she performed genome-wide linkage scan in multiply affected pedigrees, initiated and assembled the first large genome scan meta-analysis, involving many investigators in multiple countries. She has been involved in genome-wide association studies for bipolar disorder. She cloned neurobiologically relevant genes including rat MAPK (ERK1), human CALM 2 and human glucocorticoid receptor gene and characterized its promoter. She also cloned IMPA2, which encodes myoinositol monophosphatase, an enzyme known to be inhibited by lithium. In line with her interest in systems genetics of bipolar disorder, recently she generated molecular interaction networks which revealed enriched pathways for lithium-responsive genes and bipolar disorder candidate genes. She is pursuing studies on cellular modeling of bipolar disorder through induced pluripotent stem cells and is involved in a collaborative effort with the Institute for Systems Biology to perform whole genome sequencing in multigenerational multiply affected bipolar pedigrees to identify disease-segregating variants.
研究兴趣
论文共 67 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn