The research of our team targets the cellular and network mechanisms that underlie motor control and motor skill learning or the encoding of procedural learning. The Basal Ganglia (BG) network is crucial in these processes constituting an interconnected neural network involved in adaptive control of behaviour. Basal ganglia are deeply disturbed in human diseases characterized by either movement disorders as Parkinson’s and Huntington’s diseases or by cognitive defects as in drug addiction. Our projects aim to identify the involvement in BG functions and dysfunctions of specific neuronal populations, as the Medium Spiny Neurons (iMSNs and dMSNs) in the matrix and striosomes of the striatum or the prototypical and arkypallidal neurons of the Globus pallidus.