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Our general research program is to understand how the brain controls motor activity and by what mechanisms aging or certain neurodegenerative pathologies such as Parkinson Disease , alter this function.
We seek to identify neuronal networks involved in the initiation and regulation of motor activity in Drosophila, as well as the mechanisms of Circadian modulation , under the control of our internal clocks .
Our approaches combine neurogenetics and brain imaging. The use of Drosophila is justified because its motricity is easily quantifiable and more and more evolved tools make it possible to follow or modify the activity of its neurons in vivo.
In addition, models of the major human neurodegenerative diseases have been developed and are currently being studied in this organism.
We seek to identify neuronal networks involved in the initiation and regulation of motor activity in Drosophila, as well as the mechanisms of Circadian modulation , under the control of our internal clocks .
Our approaches combine neurogenetics and brain imaging. The use of Drosophila is justified because its motricity is easily quantifiable and more and more evolved tools make it possible to follow or modify the activity of its neurons in vivo.
In addition, models of the major human neurodegenerative diseases have been developed and are currently being studied in this organism.
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论文共 74 篇作者统计合作学者相似作者
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Céline Petitgas,Laurent Seugnet,Amina Dulac,Ali Mteyrek,Rebecca Fima, Marion Strehaiano, Joana Dagorret,Baya Chérif-Zahar, Sandrine Marie,Irène Ceballos-Picot,Serge Birman
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Nicolas Mathas,Gabrielle Poncet,Catherine Laurent, Lucie Larigot,Beatrice Le-Grand,Elodie Gonis,Serge Birman,Erwan Galardon, Marie-Agnes Sari, Mounira Tiouaini,Pierre Nioche,Robert Barouki,
user-5d8054e8530c708f9920ccce(2021)
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