Sebastien Degorce - †Oncology Innovative Medicines Unit, AstraZeneca

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Papers共 55 篇Author StatisticsCo-AuthorSimilar Experts

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Discovery of 6-Fluoro-5-{4-[(5-fluoro-2-methyl-3-oxo-3,4-dihydroquinoxalin-6-yl)methyl]piperazin-1-yl}-n-methylpyridine-2-carboxamide (AZD9574): A CNS-Penetrant, PARP1-Selective Inhibitor

Journal of medicinal chemistryno. 24 (2024): 21717-21728

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Discovery of 6-Fluoro-5-{4-[(5-fluoro-2-methyl-3-oxo-3,4-dihydroquinoxalin-6-yl)methyl]piperazin-1-yl}-n-methylpyridine-2-carboxamide (AZD9574): A CNS-Penetrant, PARP1-Selective Inhibitor

Journal of Medicinal Chemistry (2024)

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Discovery and Characterisation of Quinazolines and 8-Azaquinazolines As NLRP3 Agonists with Oral Bioavailability in Mice

Daniel H. O'Donovan,David Baker,Giovanni Ciotta,Sebastien L. Degorce,Sylvain Demanze,Milly Dockerill,Leire Escudero-Ibarz,Lucy Ireland,Yumeng Mao,Martin J. Packer,James Robinson,Graeme Scarfe,Haoran Tang,Viia Valge-Archer

Bioorganic & Medicinal Chemistry Letters (2023): 129518-129518

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Discovery, Preclinical Validation and Early Human Imaging with [11C]AZ14193391 – the First Blood-Brain Barrier Permeable and Subtype Selective PARP1 PET Radioligand

Miguel Angel Cortes Gonzalez,Aurelija Jucaite,Zsolt Cselenyi,Peter Johnstrom,Andy Pike,Antonia Hognasbacka,Kenneth Dahl,Amber Balazs,Sebastien Degorce,Avipsa Ghosh, Sudir Hande,Jeffrey Johannes, Anna Staniewska, Elizabetta Leo, Petra Hammerlik,Barry Davies, Sabrina Cosulich,John Swales,Rachel Lawrence,Per Stenkrona,Lars Farde,Christer Halldin,Magnus Schou

NUCLEAR MEDICINE AND BIOLOGY (2023): S55-S55

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Design of Rigid Protein-Protein Interaction Inhibitors Enables Targeting of Undruggable Mcl-1

David Hargreaves,Rodrigo J. Carbajo,Michael S. Bodnarchuk,Kevin Embrey,Philip B. Rawlins,Martin Packer,Sebastien L. Degorce,Alexander W. Hird,Jeffrey W. Johannes,Elisabetta Chiarparin,Markus Schade

Proceedings of the National Academy of Sciencesno. 21 (2023)

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Evaluation of the CNS Penetration of a Next Generation PARP Inhibitor, AZD9574, in Cynomolgus Monkey Using Positron Emission Tomography

Andy Pike,Amber Balazs,Zsolt Cselenyi,Sebastien L. Degorce,Avipsa Ghosh,Sudhir M. Hande,Jeffrey Johannes,Peter Johnstrom,Martin J. Packer,Magnus Schou,XiaoLan Zheng

CANCER RESEARCHno. 12 (2022)

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