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The compartments of the secretory and endocytic pathways are connected by membrane-bound carriers that bud from, and then fuse with, specific organelles. The accuracy of this traffic depends on the organelles having an ‘identity’ by which the trafficking machinery can recognise them. This identity is defined by organelle-specific G proteins of the Arf and Rab families and by phosphoinositide lipids.
We are interested in how active G proteins are generated in a spatially restricted manner, and what cytosolic proteins or ‘effectors’ then recognise them.
Our work is focussed on the Golgi apparatus, an organelle that plays a central role in the sorting and modification of proteins in the secretory pathway. The Golgi contains a number of Arf and Rab proteins, and we apply biochemical and genetic methods to identify their interacting partners both in mammalian tissue culture cells and in Drosophila.
We are interested in how active G proteins are generated in a spatially restricted manner, and what cytosolic proteins or ‘effectors’ then recognise them.
Our work is focussed on the Golgi apparatus, an organelle that plays a central role in the sorting and modification of proteins in the secretory pathway. The Golgi contains a number of Arf and Rab proteins, and we apply biochemical and genetic methods to identify their interacting partners both in mammalian tissue culture cells and in Drosophila.
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Molecular systems biology (2024)
PLoS biologyno. 8 (2023): e3002222-e3002222
FEBS LETTERSno. 6 (2023): 734-749
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Jérôme Cattin-Ortolá,Jonathan G. G. Kaufman, Alison K Gillingham, Jane L Wagstaff,Sew-Yeu Peak-Chew, Tim J Stevens,David J Owen,Sean Munro
biorxiv(2023)
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Joao Rocha, Satish Arcot Jayaram,Tim J. Stevens,Nadine Muschalik,Rajen D. Shah, Sahar Emran,Cristina Robles,Matthew Freeman,Sean Munro
biorxiv(2022)
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