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Dr. Cutler's research focuses on understanding and manipulating plant responses to drought. His laboratory uses a combination of chemical, biochemical, and genetic approaches to dissect the mechanism of action of ABA, a central regulator of plant stress responses. When Dr. Cutler started his laboratory, a long-standing and unresolved question was: how is ABA perceived? Previous attempts to answer this question using mutational analyses had turned up empty-handed. We now know, due to Dr. Cutler's work and that of others, that this is because multiple receptors perceive ABA. As a result, removing any single receptor is not sufficient to disrupt signaling on its own, which hampered genetic analyses. Dr. Cutler's laboratory took a chemical approach to the problem and identified a synthetic ABA mimic called pyrabactin, which selectively activates a subset of ABA responses. His group then used pyrabactin as a form of biochemical "bait" and used it to identify the first ABA receptor. This pivotal discovery has opened the door to both chemical and genetic improvement of crop tolerance to drought. His lab has since developed synthetic ABA mimics to serve as next-generation agrochemical tools for mitigating the effects of drought stress on agriculture. More recently, his laboratory has used synthetic biology approaches to reprogram plants so that traits of interest, such as drought tolerance or flowering can be controlled at will with environmentally benign chemicals.
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Aida Tafrishi,Varun Trivedi,Zenan Xing,Mengwan Li, Ritesh Mewalal,Sean Cutler,Ian Blaby,Ian Wheeldon
biorxiv(2024)
Nicolas Daffern,Kristoffer E. Johansson, Zachary T. Baumer, Nicholas R. Robertson, Janty Woojuh,Matthew A. Bedewitz, Zoë Davis,Ian Wheeldon,Sean R. Cutler,Kresten Lindorff-Larsen,Timothy A. Whitehead
Nature chemical biologyno. 1 (2023): 103-+
NATURE PLANTSno. 6 (2023): 1001-1001
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