Scott's research interests over time have covered a wide range of topics within Human-Computer Interaction, but have a center of gravity in technical aspects of HCI. They have generally included the invention and building of things which lead to a better user experience, or enabling of new capabilities for new sets of people (although often indirectly through tools).

Much of Scott's recent work has focused on computational fabrication, including topics such as: the creation of unique new types of 3D printers, the use of knitting and weaving machines as fabrication devices, tools for computational design and the use of advanced fabrication for assistive devices. His older work has explored areas such as: handling inputs with uncertainty, interactive devices, sensing, and physical interaction, managing human attention, situationally appropriate interaction, and tools and toolkits for user interface implementation.